PDBsum entry 3tcn

Hydrolase

PDB id: 3tcn

Contents

Protein chains

182 a.a.

Waters ×341

PDB id:

3tcn

Name:

Hydrolase

Title:

Crystal structures of peptidyl-tRNA hydrolase from mycobacterium tuberculosis - form 2 grown in presence of pentaglycine

Structure:

Peptidyl-tRNA hydrolase. Chain: a, b. Synonym: pth. Engineered: yes

Source:

Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: mt1042, mtcy10g2.35, pth, rv1014c. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.30Å R-factor: 0.180 R-free: 0.228

Authors:

M.Selvaraj,R.Ahmad,U.Varshney,M.Vijayan

Key ref:

M.Selvaraj et al. (2012). Structures of new crystal forms of Mycobacterium tuberculosis peptidyl-tRNA hydrolase and functionally important plasticity of the molecule. Acta Crystallogr Sect F Struct Biol Cryst Commun, 68, 124-128. PubMed id: 22297982 DOI: 10.1107/S1744309111052341

Date:

09-Aug-11 Release date: 15-Feb-12

Protein chains

P9WHN7  (PTH_MYCTU) -  Peptidyl-tRNA hydrolase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Seq: 191 a.a.

Struc: 182 a.a.

Enzyme reactions

• Enzyme class: E.C.3.1.1.29 - peptidyl-tRNA hydrolase.
• Reaction: an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1107/S1744309111052341

Acta Crystallogr Sect F Struct Biol Cryst Commun 68:124-128 (2012)

PubMed id: 22297982

Structures of new crystal forms of Mycobacterium tuberculosis peptidyl-tRNA hydrolase and functionally important plasticity of the molecule.

M.Selvaraj, R.Ahmad, U.Varshney, M.Vijayan.

ABSTRACT

No abstract given.