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PDBsum entry 3ss4
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PDB id:
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Hydrolase
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Title:
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Crystal structure of mouse glutaminasE C, phosphate-bound form
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Structure:
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GlutaminasE C. Chain: a, b, c, d. Fragment: unp residues 134-609. Engineered: yes
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Source:
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Mus musculus. Mouse. Organism_taxid: 10090. Gene: gls, gls1, mkiaa0838. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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2.85Å
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R-factor:
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0.229
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R-free:
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0.270
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Authors:
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A.L.B.Ambrosio,S.M.G.Dias,R.A.Cerione
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Key ref:
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A.Cassago
et al.
(2012).
Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism.
Proc Natl Acad Sci U S A,
109,
1092-1097.
PubMed id:
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Date:
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07-Jul-11
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Release date:
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11-Jan-12
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PROCHECK
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Headers
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References
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D3Z7P3
(GLSK_MOUSE) -
Glutaminase kidney isoform, mitochondrial from Mus musculus
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Seq:
Struc:
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674 a.a.
390 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.3.5.1.2
- glutaminase.
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Reaction:
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L-glutamine + H2O = L-glutamate + NH4+
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L-glutamine
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+
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H2O
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=
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L-glutamate
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+
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NH4(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Proc Natl Acad Sci U S A
109:1092-1097
(2012)
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PubMed id:
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Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism.
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A.Cassago,
A.P.Ferreira,
I.M.Ferreira,
C.Fornezari,
E.R.Gomes,
K.S.Greene,
H.M.Pereira,
R.C.Garratt,
S.M.Dias,
A.L.Ambrosio.
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ABSTRACT
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Links
