PDBsum entry 3sp5

Peptide binding protein

PDB id: 3sp5

Contents

Protein chain

235 a.a.

Ligands

LYS-ARG-ARG-LYS-SEP-VAL

CX7

Metals

_MG ×2

Waters ×305

PDB id:

3sp5

Name:

Peptide binding protein

Title:

Crystal structure of human 14-3-3 sigma c38v/n166h in complex with task-3 peptide and stabilizer cotylenol

Structure:

14-3-3 protein sigma. Chain: a. Synonym: epithelial cell marker protein 1, stratifin. Engineered: yes. Mutation: yes. Task-3 peptide. Chain: p. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hme1, sfn. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: this sequence occurs naturally in humans

Resolution:

1.80Å R-factor: 0.164 R-free: 0.211

Authors:

C.Anders,B.Schumacher,C.Ottmann

Key ref:

C.Anders et al. (2013). A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem Biol, 20, 583-593. PubMed id: 23601647 DOI: 10.1016/j.chembiol.2013.03.015

Date:

01-Jul-11 Release date: 04-May-16

Protein chain

P31947  (1433S_HUMAN) -  14-3-3 protein sigma from Homo sapiens

Seq: 248 a.a.

Struc: 235 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

DOI no: 10.1016/j.chembiol.2013.03.015

Chem Biol 20:583-593 (2013)

PubMed id: 23601647

A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface.

C.Anders, Y.Higuchi, K.Koschinsky, M.Bartel, B.Schumacher, P.Thiel, H.Nitta, R.Preisig-Müller, G.Schlichthörl, V.Renigunta, J.Ohkanda, J.Daut, N.Kato, C.Ottmann.

ABSTRACT

No abstract given.