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PDBsum entry 3rmy
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PDB id:
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Toxin
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Title:
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Crystal structure of hcr/d w1238a mutant
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Structure:
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Botulinum neurotoxin type d. Chain: a, b, c, d. Fragment: receptor binding domain (unp residues 862-1276). Synonym: bont/d, bontoxilysin-d, botulinum neurotoxin d heavy chain. Engineered: yes. Mutation: yes
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Source:
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Clostridium botulinum. Organism_taxid: 1491. Strain: d-1873. Gene: botd, botulinum neurotoxin d. Expressed in: escherichia coli. Expression_system_taxid: 511693.
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Resolution:
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2.30Å
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R-factor:
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0.232
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R-free:
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0.269
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Authors:
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Z.Fu,A.Karalewitz,A.Kroken,J.-J.P.Kim,J.T.Barbieri
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Key ref:
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A.R.Kroken
et al.
(2011).
Novel ganglioside-mediated entry of botulinum neurotoxin serotype D into neurons.
J Biol Chem,
286,
26828-26837.
PubMed id:
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Date:
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21-Apr-11
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Release date:
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01-Jun-11
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PROCHECK
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Headers
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References
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P19321
(BXD_CBDP) -
Botulinum neurotoxin type D from Clostridium botulinum D phage
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Seq:
Struc:
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1276 a.a.
401 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.3.4.24.69
- bontoxilysin.
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Reaction:
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Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
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Cofactor:
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Zn(2+)
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J Biol Chem
286:26828-26837
(2011)
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PubMed id:
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Novel ganglioside-mediated entry of botulinum neurotoxin serotype D into neurons.
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A.R.Kroken,
A.P.Karalewitz,
Z.Fu,
J.J.Kim,
J.T.Barbieri.
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ABSTRACT
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Links
