PDBsum entry 3rj3

Protein binding

PDB id: 3rj3

Contents

Protein chains

292 a.a.

125 a.a.

107 a.a.

Ligands

GOL ×4

Waters ×372

PDB id:

3rj3

Name:

Protein binding

Title:

Complement components factor h ccp19-20 (s1191l mutant) and c3d in complex

Structure:

Complement c3d fragment. Chain: a, b, c. Fragment: unp residues 996-1303. Synonym: c3d. Engineered: yes. Complement factor h-related protein 1. Chain: d, e, f. Fragment: unp residues 206-330. Synonym: fhr-1, h factor-like protein 1, h-factor-like 1, h36.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: c3, cpamd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: cfhr1, cfhl, cfhl1, cfhl1p, cfhr1p, fhr1, hfl1, hfl2. Expressed in: pichia pastoris. Expression_system_taxid: 4922

Resolution:

2.35Å R-factor: 0.193 R-free: 0.232

Authors:

H.P.Morgan,J.P.Hannan

Key ref:

A.P.Herbert et al. (2012). Structural and functional characterization of the product of disease-related factor H gene conversion. Biochemistry, 51, 1874-1884. PubMed id: 22320225

Date:

15-Apr-11 Release date: 14-Mar-12

Protein chains

P01024  (CO3_HUMAN) -  Complement C3 from Homo sapiens

Seq: 1663 a.a.

Struc: 292 a.a.*

Protein chains

P08603  (CFAH_HUMAN) -  Complement factor H from Homo sapiens

Seq: 1231 a.a.

Struc: 125 a.a.*

Protein chain

P08603  (CFAH_HUMAN) -  Complement factor H from Homo sapiens

Seq: 1231 a.a.

Struc: 107 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Biochemistry 51:1874-1884 (2012)

PubMed id: 22320225

Structural and functional characterization of the product of disease-related factor H gene conversion.

A.P.Herbert, D.Kavanagh, C.Johansson, H.P.Morgan, B.S.Blaum, J.P.Hannan, P.N.Barlow, D.Uhrín.

ABSTRACT

No abstract given.