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PDBsum entry 3q2v
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protein ligands metals Protein-protein interface(s) links
Cell adhesion PDB id
3q2v

 

 

 

 

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Contents
Protein chains
532 a.a.
440 a.a.
Ligands
MAN ×18
Metals
_CA ×24
_MN ×2
Waters ×135
PDB id:
3q2v
Name: Cell adhesion
Title: Crystal structure of mouse e-cadherin ectodomain
Structure: Cadherin-1. Chain: a, b. Fragment: unp residues 157-700. Synonym: arc-1, epithelial cadherin, e-cadherin, uvomorulin, e- cad/ctf1, e-cad/ctf2, e-cad/ctf3. Engineered: yes
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: cdh1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293.
Resolution:
3.40Å     R-factor:   0.233     R-free:   0.293
Authors: X.Jin,O.J.Harrison,L.Shapiro
Key ref: O.J.Harrison et al. (2011). The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. Structure, 19, 244-256. PubMed id: 21300292
Date:
20-Dec-10     Release date:   06-Apr-11    
PROCHECK
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 Headers
 References

Protein chain
P09803  (CADH1_MOUSE) -  Cadherin-1 from Mus musculus
Seq:
Struc: 		 
Seq:
Struc: 		884 a.a.
532 a.a.
Protein chain
P09803  (CADH1_MOUSE) -  Cadherin-1 from Mus musculus
Seq:
Struc: 		 
Seq:
Struc: 		884 a.a.
440 a.a.*
Key:    Secondary structure  CATH domain
* PDB and UniProt seqs differ at 5 residue positions (black crosses)

 

 
Structure 19:244-256 (2011)
PubMed id: 21300292  
 
 
The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins.
O.J.Harrison, X.Jin, S.Hong, F.Bahna, G.Ahlsen, J.Brasch, Y.Wu, J.Vendome, K.Felsovalyi, C.M.Hampton, R.B.Troyanovsky, A.Ben-Shaul, J.Frank, S.M.Troyanovsky, L.Shapiro, B.Honig.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
22931853 A.Ratheesh, and A.S.Yap (2012).
A bigger picture: classical cadherins and the dynamic actin cytoskeleton.
  Nat Rev Mol Cell Biol, 13, 673-679.  
21269602 J.Brasch, O.J.Harrison, G.Ahlsen, S.M.Carnally, R.M.Henderson, B.Honig, and L.Shapiro (2011).
Structure and binding mechanism of vascular endothelial cadherin: a divergent classical cadherin.
  J Mol Biol, 408, 57-73.
PDB code: 3ppe
21572446 J.Vendome, S.Posy, X.Jin, F.Bahna, G.Ahlsen, L.Shapiro, and B.Honig (2011).
Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins.
  Nat Struct Mol Biol, 18, 693-700.
PDB code: 3qrb
21796210 Y.Wu, J.Vendome, L.Shapiro, A.Ben-Shaul, and B.Honig (2011).
Transforming binding affinities from three dimensions to two with application to cadherin clustering.
  Nature, 475, 510-513.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

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