PDBsum entry 3pyk

Lyase/lyase inhibitor

PDB id: 3pyk

Contents

Protein chain

258 a.a.

Ligands

SRX

MMC

SO4

Metals

_ZN

Waters ×420

PDB id:

3pyk

Name:

Lyase/lyase inhibitor

Title:

Human carbonic anhydrase ii as host for pianostool complexes bearing a sulfonamide anchor

Structure:

Carbonic anhydrase 2. Chain: a. Synonym: carbonate dehydratase ii, carbonic anhydrasE C, cac, carbonic anhydrase ii, ca-ii. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.30Å R-factor: 0.129 R-free: 0.165

Authors:

T.Heinisch,T.Schirmer

Key ref:

F.W.Monnard et al. (2011). Human carbonic anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor. Chem Commun (camb), 47, 8238-8240. PubMed id: 21706094

Date:

13-Dec-10 Release date: 13-Jul-11

Protein chain

P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2 from Homo sapiens

Seq: 260 a.a.

Struc: 258 a.a.

Enzyme reactions

• Enzyme class: E.C.4.2.1.1 - carbonic anhydrase.
• Reaction: hydrogencarbonate + H⁺ = CO2 + H2O
• Cofactor: Zn(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Chem Commun (camb) 47:8238-8240 (2011)

PubMed id: 21706094

Human carbonic anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor.

F.W.Monnard, T.Heinisch, E.S.Nogueira, T.Schirmer, T.R.Ward.

ABSTRACT

No abstract given.