PDBsum entry 3pln

Oxidoreductase

PDB id: 3pln

Contents

Protein chain

379 a.a.

Ligands

U5P

Waters ×664

PDB id:

3pln

Name:

Oxidoreductase

Title:

Crystal structure of klebsiella pneumoniae udp-glucose 6-dehydrogenase complexed with udp-glucose

Structure:

Udp-glucose 6-dehydrogenase. Chain: a. Engineered: yes

Source:

Klebsiella pneumoniae. Organism_taxid: 484021. Strain: ntuh-k2044. Gene: kp1_3701, ugd. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.50Å R-factor: 0.164 R-free: 0.190

Authors:

Y.-Y.Chen,T.-P.Ko,C.-H.Lin,W.-H.Chen,A.H.-J.Wang

Key ref:

Y.Y.Chen et al. (2011). Conformational change upon product binding to Klebsiella pneumoniae UDP-glucose dehydrogenase: a possible inhibition mechanism for the key enzyme in polymyxin resistance. J Struct Biol, 175, 300-310. PubMed id: 21536136

Date:

15-Nov-10 Release date: 28-Sep-11

Protein chain

A0A0J9WZA6  (A0A0J9WZA6_KLEPN) -  UDP-glucose 6-dehydrogenase from Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044

Seq: 388 a.a.

Struc: 379 a.a.

Enzyme reactions

• Enzyme class: E.C.1.1.1.22 - UDP-glucose 6-dehydrogenase.
• Pathway: UDP-glucose, UDP-galactose and UDP-glucuronate Biosynthesis
• Reaction: UDP-alpha-D-glucose + 2 NAD⁺ + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H⁺

UDP-alpha-D-glucose + 2 × NAD(+) + H2O (Bound ligand (Het Group name = U5P) matches with 58.33% similarity) = UDP-alpha-D-glucuronate + 2 × NADH + 3 × H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

J Struct Biol 175:300-310 (2011)

PubMed id: 21536136

Conformational change upon product binding to Klebsiella pneumoniae UDP-glucose dehydrogenase: a possible inhibition mechanism for the key enzyme in polymyxin resistance.

Y.Y.Chen, T.P.Ko, C.H.Lin, W.H.Chen, A.H.Wang.

ABSTRACT

No abstract given.