PDBsum entry 3o3e

Immune system

PDB id

3o3e

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Contents

			Protein chains

					275 a.a. *


					100 a.a. *

			Ligands

					BAL-LEU-ALA-TIG- 3AZ-LEU-THR-VAL ×2


					GOL ×4

			Waters ×578

* Residue conservation analysis

PDB id:

3o3e

Links

Name:

Immune system

Title:

Human class i mhc hla-a2 in complex with the peptidomimetic ela-2.1

Structure:

Hla class i histocompatibility antigen, a-2 alpha chain. Chain: a, d. Fragment: unp residues 25-298. Synonym: mhc class i antigen a 2. Engineered: yes. Beta-2-microglobulin. Chain: b, e. Synonym: beta-2-microglobulin form pi 5.3. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-a, hlaa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: b2m, cdabp0092, hdcma22p. Synthetic: yes

Resolution:

1.85Å

R-factor:

0.185

R-free:

0.230

Authors:

O.Y.Borbulevych,B.M.Baker

Key ref:

C.Douat-Casassus et al. (2010). Crystal structures of HLA-A*0201 complexed with Melan-A/MART-1(26(27L)-35) peptidomimetics reveal conformational heterogeneity and highlight degeneracy of T cell recognition. J Med Chem, 53, 7061-7066. PubMed id: 20806940

Date:

23-Jul-10

Release date:

08-Dec-10

PROCHECK

	Headers

	References

Protein chains

P04439 (1A03_HUMAN) - HLA class I histocompatibility antigen, A alpha chain from Homo sapiens

Seq: Struc:					365 a.a. 275 a.a.*

Protein chains

P61769 (B2MG_HUMAN) - Beta-2-microglobulin from Homo sapiens

Seq: Struc:					119 a.a. 100 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 20 residue positions (black crosses)

	J Med Chem 53:7061-7066 (2010)
PubMed id: 20806940

Crystal structures of HLA-A*0201 complexed with Melan-A/MART-1(26(27L)-35) peptidomimetics reveal conformational heterogeneity and highlight degeneracy of T cell recognition.
C.Douat-Casassus, O.Borbulevych, M.Tarbe, N.Gervois, F.Jotereau, B.M.Baker, S.Quideau.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

21332270

N.P.Croft, and A.W.Purcell (2011).
Peptidomimetics: modifying peptides in the pursuit of better vaccines.

Expert Rev Vaccines, 10, 211-226.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.