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PDBsum entry 3n0t
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Contents |
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* Residue conservation analysis
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PDB id:
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Hydrolase
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Title:
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Human dipeptidil peptidase dpp7 complexed with inhibitor gsk237826a
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Structure:
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Dipeptidyl peptidase 2. Chain: a, b, c, d. Fragment: peptidase domain (unp residues 28-492). Synonym: dipeptidyl peptidase ii, dpp ii, dipeptidyl aminopeptidase ii, quiescent cell proline dipeptidase, dipeptidyl peptidase 7. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: dpp2, dpp7, qpp. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
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Resolution:
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2.45Å
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R-factor:
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0.221
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R-free:
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0.260
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Authors:
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E.Dobrovetsky,G.Khutoreskaya,A.Seitova,L.Crombet,D.Cossar,S.Pagannon, C.H.Arrowsmith,C.Bountra,J.Weigelt,A.M.Edwards,A.Hassell,L.Shewchuk, C.Haffner,A.Bochkarev,Structural Genomics Consortium (Sgc)
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Key ref:
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E.Dobrovetsky
et al.
Human dipeptidyl peptidase dpp7.
To be published,
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Date:
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14-May-10
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Release date:
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21-Jul-10
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PROCHECK
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Headers
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References
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Q9UHL4
(DPP2_HUMAN) -
Dipeptidyl peptidase 2 from Homo sapiens
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Seq:
Struc:
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492 a.a.
452 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.3.4.14.2
- dipeptidyl-peptidase Ii.
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Reaction:
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Release of an N-terminal dipeptide, Xaa-Xbb-|-Xcc, preferentially when Xbb is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides.
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Links
