PDBsum entry 3m2y

Lyase/lyase inhibitor

PDB id: 3m2y

Contents

Protein chain

258 a.a.

Ligands

BE0 ×2

BE7

Metals

_ZN ×2

_HG

Waters ×266

PDB id:

3m2y

Name:

Lyase/lyase inhibitor

Title:

Carbonic anhydrase ii in complex with novel sulfonamide inhibitor

Structure:

Carbonic anhydrase 2. Chain: a. Fragment: carbonic anhydrase ii. Synonym: carbonic anhydrase ii, ca-ii, carbonate dehydratase ii, carbonic anhydrasE C, cac. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.17Å R-factor: 0.128 R-free: 0.161

Authors:

J.Schulze Wischeler,A.Heine,G.Klebe

Key ref:

J.Schulze wischeler et al. Structural investigation and inhibitor stuies on carb anhydrase ii. To be published, .

Date:

08-Mar-10 Release date: 25-May-11

Protein chain

P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2 from Homo sapiens

Seq: 260 a.a.

Struc: 258 a.a.

Enzyme reactions

• Enzyme class 2: E.C.4.2.1.1 - carbonic anhydrase.
• Reaction: hydrogencarbonate + H⁺ = CO2 + H2O
• Cofactor: Zn(2+)
• Enzyme class 3: E.C.4.2.1.69 - cyanamide hydratase.
• Reaction: urea = cyanamide + H2O

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site