PDBsum entry 3ls8

Transferase

PDB id: 3ls8

Contents

Protein chain

547 a.a. *

Ligands

AJZ ×2

GOL

Metals

_CL ×4

Waters ×260

* Residue conservation analysis

PDB id:

3ls8

Name:

Transferase

Title:

Crystal structure of human pik3c3 in complex with 3-[4-(4- morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol

Structure:

Phosphatidylinositol 3-kinase catalytic subunit type 3. Chain: a, b. Fragment: unp residues 268-879. Synonym: ptdins-3-kinase type 3, pi3-kinase type 3, pi3k type 3, phosphoinositide-3-kinase class 3, phosphatidylinositol 3-kinase p100 subunit. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pik3c3. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.25Å R-factor: 0.211 R-free: 0.251

Authors:

L.Tresaugues,M.Welin,C.H.Arrowsmith,H.Berglund,C.Bountra,R.Collins, A.M.Edwards,S.Flodin,A.Flores,S.Graslund,M.Hammarstrom,I.Johansson, T.Karlberg,T.Kotenyova,P.Kraulis,M.Moche,T.Nyman,C.Persson, H.Schuler,P.Schutz,M.I.Siponen,A.G.Thorsell,S.Van Den Berg, E.Wahlberg,J.Weigelt,M.Wisniewska,P.Nordlund,Structural Genomics Consortium (Sgc)

Key ref:

L.Tresaugues et al. Crystal structure of human pik3c3 in complex with 3-[4-(4-Morpholinyl)thieno[3,2-D]pyrimidin-2-Yl]- Phenol. To be published, .

Date:

12-Feb-10 Release date: 23-Mar-10

Protein chains

Q8NEB9  (PK3C3_HUMAN) -  Phosphatidylinositol 3-kinase catalytic subunit type 3 from Homo sapiens

Seq: 887 a.a.

Struc: 547 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.1.137 - phosphatidylinositol 3-kinase.
• Pathway: 1-Phosphatidyl-myo-inositol Metabolism
• Reaction: a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl- sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site