PDBsum entry 3jql

Hydrolase

PDB id: 3jql

Contents

Protein chain

119 a.a. *

Ligands

LYS-LEU-VAL-PHE-PHE-ALA

Metals

_CA

Waters ×149

* Residue conservation analysis

PDB id:

3jql

Name:

Hydrolase

Title:

Crystal structure of the complex formed between phospholipase a2 and a hexapeptide fragment of amyloid beta peptide, lys-leu-val-phe-phe-ala at 1.2 a resolution

Structure:

Acidic phospholipase a2 3 (fragment). Chain: a. Amyloid beta peptide. Chain: b. Engineered: yes

Source:

Naja sagittifera. Organism_taxid: 195058. Synthetic: yes. Other_details: peptide synthesis

Resolution:

1.20Å R-factor: 0.187 R-free: 0.193

Authors:

Z.Mirza,G.Vikram,N.Singh,M.Sinha,S.Sharma,A.Srinivasan,P.Kaur, T.P.Singh

Key ref:

Z.Mirza et al. Crystal structure of the complex formed between phospholipase a2 and a hexapeptide fragment of amyloid beta peptide, Lys-Leu-Val-Phe-Phe-Ala at 1.2 a resolution. To be published, .

Date:

07-Sep-09 Release date: 29-Sep-09

Protein chain

P60045  (PA2A3_NAJSG) -  Acidic phospholipase A2 3 (Fragment) from Naja sagittifera

Seq: 126 a.a.

Struc: 119 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.1.1.4 - phospholipase A2.
• Reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3- phosphocholine + a fatty acid + H⁺
• Cofactor: Ca(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site