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PDBsum entry 3cos
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Oxidoreductase
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PDB id
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3cos
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Contents |
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* Residue conservation analysis
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PDB id:
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| Name: |
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Oxidoreductase
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Title:
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Crystal structure of human class ii alcohol dehydrogenase (adh4) in complex with NAD and zn
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Structure:
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Alcohol dehydrogenase 4. Chain: a, b, c, d. Synonym: alcohol dehydrogenase class ii pi chain. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: adh4. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
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Resolution:
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2.10Å
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R-factor:
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0.170
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R-free:
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0.206
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Authors:
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K.L.Kavanagh,N.Shafqat,W.Yue,F.Von Delft,S.Bishop,A.Roos,J.Murray, A.M.Edwards,C.H.Arrowsmith,C.Bountra,U.Oppermann,Structural Genomics Consortium (Sgc)
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Key ref:
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K.L.Kavanagh
et al.
Crystal structure of human class ii alcohol dehydrogenase (adh4) in complex with NAD and zn..
To be published,
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Date:
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29-Mar-08
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Release date:
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15-Apr-08
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PROCHECK
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Headers
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References
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P08319
(ADH4_HUMAN) -
All-trans-retinol dehydrogenase [NAD(+)] ADH4 from Homo sapiens
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Seq:
Struc:
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380 a.a.
379 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Enzyme class:
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E.C.1.1.1.105
- all-trans-retinol dehydrogenase (NAD(+)).
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Reaction:
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all-trans-retinol--[retinol-binding protein] + NAD+ = all-trans- retinal--[retinol-binding protein] + NADH + H+
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all-trans-retinol--[retinol-binding protein]
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+
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NAD(+)
Bound ligand (Het Group name = )
corresponds exactly
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=
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all-trans- retinal--[retinol-binding protein]
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+
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NADH
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
