PDBsum entry 3c11

Chaperone/antibiotic

PDB id: 3c11

Contents

Protein chain

214 a.a. *

Ligands

GDM

GOL ×2

Waters ×299

* Residue conservation analysis

PDB id:

3c11

Name:

Chaperone/antibiotic

Title:

Yeast hsp82 n-terminal domain-geldanamycin complex: effects of mutants 98-99 ks-aa

Structure:

Atp-dependent molecular chaperone hsp82. Chain: a. Fragment: n-terminal domain (residues 1-220). Synonym: heat shock protein hsp90 heat-inducible isoform, 82 kda heat shock protein. Engineered: yes. Mutation: yes

Source:

Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: hsp82, hsp90. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.60Å R-factor: 0.191 R-free: 0.223

Authors:

R.M.Immormino,D.T.Gewirth

Key ref:

R.M.Immormino et al. Crystal structure of grp94 with the specific mutation ks168-169aa with bound geldanamycin. To be published, .

Date:

21-Jan-08 Release date: 29-Jul-08

Protein chain

P02829  (HSP82_YEAST) -  ATP-dependent molecular chaperone HSP82 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: 709 a.a.

Struc: 214 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)