PDBsum entry 3atl

Hydrolase/hydrolase inhibitor

PDB id: 3atl

Contents

Protein chain

223 a.a.

Ligands

DMS ×3

BEN

Metals

_CA

Waters ×317

PDB id:

3atl

Name:

Hydrolase/hydrolase inhibitor

Title:

Crystal structure of trypsin complexed with benzamidine

Structure:

Cationic trypsin. Chain: a. Synonym: beta-trypsin. Ec: 3.4.21.4

Source:

Bos taurus. Bovine. Organism_taxid: 9913. Tissue: pancreas

Resolution:

1.74Å R-factor: 0.161 R-free: 0.188

Authors:

J.Yamane,M.Yao,I.Tanaka

Key ref:

J.Yamane et al. (2011). In-Crystal affinity ranking of fragment hit compounds reveals a relationship with their inhibitory activiti. J appl crystallogr, 44, 798.

Date:

05-Jan-11 Release date: 24-Aug-11

Protein chain

P00760  (TRY1_BOVIN) -  Serine protease 1 from Bos taurus

Seq: 246 a.a.

Struc: 223 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.21.4 - trypsin.
• Reaction: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.