PDBsum entry 3acl

Metal binding protein

PDB id: 3acl

Contents

Protein chain

288 a.a. *

Ligands

3F1

Metals

FE2

Waters ×131

* Residue conservation analysis

PDB id:

3acl

Name:

Metal binding protein

Title:

Crystal structure of human pirin in complex with triphenyl compound

Structure:

Pirin. Chain: a. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pir. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Resolution:

2.35Å R-factor: 0.203 R-free: 0.246

Authors:

H.Okumura,I.Miyazaki,S.Simizu,H.Osada

Key ref:

I.Miyazaki et al. (2010). A small-molecule inhibitor shows that pirin regulates migration of melanoma cells. Nat Chem Biol, 6, 667-673. PubMed id: 20711196

Date:

05-Jan-10 Release date: 18-Aug-10

Protein chain

O00625  (PIR_HUMAN) -  Pirin from Homo sapiens

Seq: 290 a.a.

Struc: 288 a.a.

Enzyme reactions

• Enzyme class: E.C.1.13.11.24 - quercetin 2,3-dioxygenase.
• Pathway: Quercetin 2,3-Dioxygenase
• Reaction: quercetin + O2 = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO

quercetin + O2 (Bound ligand (Het Group name = 3F1) matches with 40.00% similarity) = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO

• Cofactor: Fe cation or Cu cation

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Nat Chem Biol 6:667-673 (2010)

PubMed id: 20711196

A small-molecule inhibitor shows that pirin regulates migration of melanoma cells.

I.Miyazaki, S.Simizu, H.Okumura, S.Takagi, H.Osada.

ABSTRACT

No abstract given.