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PDBsum entry 2yi7
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PDB id:
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Chaperone
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Title:
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Structural characterization of 5-aryl-4-(5-substituted-2-4- dihydroxyphenyl)-1,2,3-thiadiazole hsp90 inhibitors.
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Structure:
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Heat shock protein hsp 90-alpha. Chain: a. Fragment: n-terminal domain, residues 1-229. Synonym: hsp90, heat shock 86 kda, hsp 86, hsp86, renal carcinoma antigen ny-ren-38. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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1.40Å
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R-factor:
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0.176
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R-free:
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0.196
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Authors:
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S.M.Roe,C.Prodromou,L.H.Pearl
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Key ref:
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S.Y.Sharp
et al.
(2012).
Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors.
Plos One,
7,
e44642.
PubMed id:
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Date:
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10-May-11
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Release date:
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16-May-12
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PROCHECK
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Headers
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References
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P07900
(HS90A_HUMAN) -
Heat shock protein HSP 90-alpha from Homo sapiens
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Seq:
Struc:
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732 a.a.
209 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.3.6.4.10
- non-chaperonin molecular chaperone ATPase.
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Reaction:
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ATP + H2O = ADP + phosphate + H+
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ATP
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+
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H2O
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=
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ADP
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+
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phosphate
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Plos One
7:e44642
(2012)
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PubMed id:
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Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors.
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S.Y.Sharp,
S.M.Roe,
E.Kazlauskas,
I.Cikotienė,
P.Workman,
D.Matulis,
C.Prodromou.
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ABSTRACT
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