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PDBsum entry 2yf0
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PDB id:
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Hydrolase
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Title:
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Human myotubularin related protein 6 (mtmr6)
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Structure:
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Myotubularin-related protein 6. Chain: a. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3 prare. Other_details: mammalian gene collection
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Resolution:
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2.65Å
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R-factor:
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0.259
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R-free:
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0.288
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Authors:
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M.Moche,L.Tresaugues,C.H.Arrowsmith,H.Berglund,C.Bountra,R.Collins, A.M.Edwards,S.Flodin,A.Flores,S.Graslund,M.Hammarstrom,I.Johansson, T.Karlberg,T.Kotenyova,E.Kouznetsova,T.Nyman,C.Persson,H.Schuler, P.Schutz,M.I.Siponen,A.G.Thorsell,S.Vandenberg,E.Wahlberg,J.Weigelt, M.Welin,P.Nordlund
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Key ref:
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M.Moche
et al.
Crystal structure of human mtmr6.
To be published,
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Date:
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31-Mar-11
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Release date:
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13-Apr-11
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PROCHECK
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Headers
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References
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Q9Y217
(MTMR6_HUMAN) -
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 from Homo sapiens
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Seq:
Struc:
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621 a.a.
487 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.3.1.3.95
- phosphatidylinositol-3,5-bisphosphate 3-phosphatase.
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Reaction:
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a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
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1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate)
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+
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H2O
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=
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1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)
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+
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phosphate
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
