PDBsum entry 2yd2

Hydrolase

PDB id: 2yd2

Contents

Protein chain

197 a.a.

Metals

IOD ×4

_CL ×3

Waters ×30

PDB id:

2yd2

Name:

Hydrolase

Title:

Crystal structure of the n-terminal ig1-2 module of human receptor protein tyrosine phosphatase sigma

Structure:

Receptor-type tyrosine-protein phosphatase s. Chain: a. Fragment: ig1-2, residues 30-231. Synonym: protein tyrosine phosphatase sigma, r-ptp-s, receptor-type tyrosine-protein phosphatase sigma, r-ptp-sigma, rptps. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293t.

Resolution:

2.55Å R-factor: 0.200 R-free: 0.260

Authors:

C.H.Coles,Y.Shen,A.P.Tenney,C.Siebold,G.C.Sutton,W.Lu,J.T.Gallagher, E.Y.Jones,J.G.Flanagan,A.R.Aricescu

Key ref:

C.H.Coles et al. (2011). Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension. Science, 332, 484-488. PubMed id: 21454754

Date:

17-Mar-11 Release date: 13-Apr-11

Protein chain

Q13332  (PTPRS_HUMAN) -  Receptor-type tyrosine-protein phosphatase S from Homo sapiens

Seq: 1948 a.a.

Struc: 197 a.a.

Enzyme reactions

• Enzyme class: E.C.3.1.3.48 - protein-tyrosine-phosphatase.
• Reaction: O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Key reference

Science 332:484-488 (2011)

PubMed id: 21454754

Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension.

C.H.Coles, Y.Shen, A.P.Tenney, C.Siebold, G.C.Sutton, W.Lu, J.T.Gallagher, E.Y.Jones, J.G.Flanagan, A.R.Aricescu.

ABSTRACT

No abstract given.