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PDBsum entry 2xss
Go to PDB code:
Hydrolase
PDB id
2xss
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Contents
Protein chain
156 a.a.
PDB id:
2xss
Links
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CATH
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PDBePISA
ProSAT
Name:
Hydrolase
Title:
Crystal structure of gafb from the human phosphodiesterase 5
Structure:
Cgmp-specific 3', 5'-cyclic phosphodiesterase. Chain: a, b. Fragment: gafb domain, residues 346-508. Synonym: cgmp-binding cgmp-specific phosphodiesterase, cgb-pde. Engineered: yes
Source:
Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
2.50Å
R-factor:
0.252
R-free:
0.317
Authors:
C.Schlicker,M.Russwurm,C.Steegborn
Key ref:
M.Russwurm et al. (2011). Crystal structure of the GAF-B domain from human phosphodiesterase 5.
Proteins
,
79
, 1682-1687.
PubMed id:
21425347
Date:
30-Sep-10
Release date:
18-May-11
PROCHECK
Headers
References
Protein chains
?
O76074
(PDE5A_HUMAN) - cGMP-specific 3',5'-cyclic phosphodiesterase from Homo sapiens
Seq:
Struc:
Seq:
Struc:
875 a.a.
156 a.a.
*
Key:
PfamA domain
Secondary structure
CATH domain
*
PDB and UniProt seqs differ at 6 residue positions (black crosses)
Enzyme reactions
Enzyme class:
E.C.3.1.4.35
- 3',5'-cyclic-GMP phosphodiesterase.
[IntEnz]
[ExPASy]
[KEGG]
[BRENDA]
Reaction:
3',5'-cyclic GMP + H2O = GMP + H
+
3',5'-cyclic GMP
+
H2O
=
GMP
+
H(+)
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
Added reference
Proteins
79
:1682-1687 (2011)
PubMed id:
21425347
Crystal structure of the GAF-B domain from human phosphodiesterase 5.
M.Russwurm,
C.Schlicker,
M.Weyand,
D.Koesling,
C.Steegborn.
ABSTRACT
No abstract given.
Links
