PDBsum entry 2xs4

Hydrolase

PDB id: 2xs4

Contents

Protein chain

167 a.a. *

Ligands

ALA-PHE-THR

Metals

_CL

_MG

_ZN ×2

Waters ×196

* Residue conservation analysis

PDB id:

2xs4

Name:

Hydrolase

Title:

Structure of karilysin catalytic mmp domain in complex with magnesium

Structure:

Karilysin protease. Chain: a. Fragment: residues 35-201. Synonym: karilysin catalytic domain kly18. Engineered: yes. Peptide ala-phe-thr. Chain: b

Source:

Tannerella forsythia. Organism_taxid: 28112. Expressed in: escherichia coli. Expression_system_taxid: 511693. Synthetic construct. Organism_taxid: 32630

Resolution:

1.70Å R-factor: 0.159 R-free: 0.186

Authors:

N.Cerda-Costa,T.Guevara,A.Y.Karim,M.Ksiazek,K.-A.Nguyen,J.L.Arolas, J.Potempa,F.X.Gomis-Ruth

Key ref:

N.Cerdà-Costa et al. (2011). The structure of the catalytic domain of Tannerella forsythia karilysin reveals it is a bacterial xenologue of animal matrix metalloproteinases. Mol Microbiol, 79, 119-132. PubMed id: 21166898

Date:

24-Sep-10 Release date: 03-Nov-10

Protein chain

D0EM77  (KLY_TANFA) -  Karilysin from Tannerella forsythia (strain ATCC 43037 / JCM 10827 / CCUG 21028 A / KCTC 5666 / FDC 338)

Seq: 472 a.a.

Struc: 167 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.4.24.- - ?????

Mol Microbiol 79:119-132 (2011)

PubMed id: 21166898

The structure of the catalytic domain of Tannerella forsythia karilysin reveals it is a bacterial xenologue of animal matrix metalloproteinases.

N.Cerdà-Costa, T.Guevara, A.Y.Karim, M.Ksiazek, K.A.Nguyen, J.L.Arolas, J.Potempa, F.X.Gomis-Rüth.

ABSTRACT

No abstract given.