PDBsum entry 2xfm

RNA/protein

PDB id

2xfm

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Contents

			Protein chain

					120 a.a. *

			DNA/RNA

* Residue conservation analysis

PDB id:

2xfm

Links
- PDBe
- RCSB
- MMDB
- JenaLib
- Proteopedia
- CATH
- SCOP
- PDBSWS
- ProSAT

Name:

RNA/protein

Title:

Complex structure of the miwi paz domain bound to methylated single stranded RNA

Structure:

Piwi-like protein 1. Chain: a. Fragment: paz-domain, residues 276-425. Synonym: miwi. Engineered: yes. 5'-r( Ap Cp Cp Gp Ap Cp Up (Omu)p)-3'. Chain: b. Synonym: pirna. Engineered: yes.

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630. Other_details: based on biological sequence

NMR struc:

10 models

Authors:

B.Simon,J.P.Kirkpatrick,S.Eckhardt,P.Sehr,M.A.Andrade-Navarro, R.S.Pillai,T.Carlomagno

Key ref:

B.Simon et al. (2011). Recognition of 2'-O-methylated 3'-end of piRNA by the PAZ domain of a Piwi protein. Structure, 19, 172-180. PubMed id: 21237665

Date:

27-May-10

Release date:

26-Jan-11

PROCHECK

	Headers

	References

Protein chain

Q9JMB7 (PIWL1_MOUSE) - Piwi-like protein 1 from Mus musculus

Seq: Struc:

Seq: Struc:					862 a.a. 120 a.a.

Key:

PfamA domain

Secondary structure

CATH domain

DNA/RNA chain

A-C-C-G-A-C-U-OMU 8 bases



		Enzyme reactions

Enzyme class:

E.C.3.1.26.- - ?????

[IntEnz] [ExPASy] [KEGG] [BRENDA]

	Structure 19:172-180 (2011)
PubMed id: 21237665

Recognition of 2'-O-methylated 3'-end of piRNA by the PAZ domain of a Piwi protein.
B.Simon, J.P.Kirkpatrick, S.Eckhardt, M.Reuter, E.A.Rocha, M.A.Andrade-Navarro, P.Sehr, R.S.Pillai, T.Carlomagno.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

22842725

A.Vourekas, Q.Zheng, P.Alexiou, M.Maragkakis, Y.Kirino, B.D.Gregory, and Z.Mourelatos (2012).
Mili and Miwi target RNA repertoire reveals piRNA biogenesis and function of Miwi in spermiogenesis.

Nat Struct Mol Biol, 19, 773-781.

22767235

H.M.Sasaki, and Y.Tomari (2012).
The true core of RNA silencing revealed.

Nat Struct Mol Biol, 19, 657-660.

21557942

J.S.Mattick (2011).
The central role of RNA in human development and cognition.

FEBS Lett, 585, 1600-1616.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.