PDBsum entry 2xd6

Chaperone

PDB id: 2xd6

Contents

Protein chain

214 a.a. *

Ligands

XD6

GOL ×4

Waters ×217

* Residue conservation analysis

PDB id:

2xd6

Name:

Chaperone

Title:

Hsp90 complexed with a resorcylic acid macrolactone.

Structure:

Atp-dependent molecular chaperone hsp82. Chain: a. Fragment: n-terminal domain, residues 1-214. Synonym: heat shock protein hsp90 heat-inducible isoform, 82 kda heat shock protein, hsp90. Engineered: yes

Source:

Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.20Å R-factor: 0.173 R-free: 0.228

Authors:

S.M.Roe,C.Prodromou,L.H.Pearl,C.J.Moody

Key ref:

J.E.Day et al. (2010). Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies. Chemistry, 16, 10366-10372. PubMed id: 20661961

Date:

29-Apr-10 Release date: 11-Aug-10

Protein chain

P02829  (HSP82_YEAST) -  ATP-dependent molecular chaperone HSP82 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: 709 a.a.

Struc: 214 a.a.

Chemistry 16:10366-10372 (2010)

PubMed id: 20661961

Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies.

J.E.Day, S.Y.Sharp, M.G.Rowlands, W.Aherne, W.Lewis, S.M.Roe, C.Prodromou, L.H.Pearl, P.Workman, C.J.Moody.

ABSTRACT

No abstract given.