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PDBsum entry 2x1h
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Oxidoreductase
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PDB id
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2x1h
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Contents |
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* Residue conservation analysis
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PDB id:
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| Name: |
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Oxidoreductase
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Title:
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Crystal structure of the human mgc45594 gene product in complex with raloxifene
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Structure:
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Zinc-binding alcohol dehydrogenase domain-containing protein 2. Chain: a, b. Fragment: residues 33-371. Synonym: mgc45594 gene product. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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1.75Å
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R-factor:
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0.210
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R-free:
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0.243
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Authors:
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N.Shafqat,W.W.Yue,A.C.W.Pike,F.Niesen,E.Ugochukwu,T.Krojer, A.Chaikuad,C.Smee,C.Arrowsmith,J.Weigelt,A.Edwards,C.Bountra, U.Oppermann
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Key ref:
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N.Shafqat
et al.
Crystal structure of the human mgc45594 gene product complex with raloxifene.
To be published,
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Date:
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24-Dec-09
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Release date:
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10-Nov-10
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PROCHECK
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Headers
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References
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Q8N4Q0
(PTGR3_HUMAN) -
Prostaglandin reductase 3 from Homo sapiens
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Seq:
Struc:
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377 a.a.
340 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Enzyme class:
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E.C.1.3.1.48
- 15-oxoprostaglandin 13-reductase.
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Reaction:
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1.
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13,14-dihydro-15-oxo-prostaglandin E2 + NADP+ = 15-oxoprostaglandin E2 + NADPH + H+
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2.
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13,14-dihydro-15-oxo-prostaglandin E2 + NAD+ = 15-oxoprostaglandin E2 + NADH + H+
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13,14-dihydro-15-oxo-prostaglandin E2
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+
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NADP(+)
Bound ligand (Het Group name = )
corresponds exactly
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=
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15-oxoprostaglandin E2
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+
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NADPH
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+
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H(+)
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13,14-dihydro-15-oxo-prostaglandin E2
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+
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NAD(+)
Bound ligand (Het Group name = )
matches with 91.67% similarity
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=
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15-oxoprostaglandin E2
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+
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NADH
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
