PDBsum entry 2wzr

Virus

PDB id: 2wzr

Contents

Protein chains

194 a.a. *

207 a.a. *

221 a.a. *

47 a.a. *

* Residue conservation analysis

PDB id:

2wzr

Name:

Virus

Title:

The structure of foot and mouth disease virus serotype sat1

Structure:

Polyprotein. Chain: 1. Fragment: residues 725-943. Polyprotein. Chain: 2. Fragment: residues 285-503. Polyprotein. Chain: 3. Fragment: residues 504-724.

Source:

Foot-and-mouth disease virus. Organism_taxid: 12122. Strain: sat1bot1/68. Strain: sat1bot1/68

Resolution:

3.00Å R-factor: 0.230

Authors:

P.Adams,S.Lea,J.Newman,W.Blakemore,A.King,D.Stuart,E.Fry

Key ref:

P.Adams et al. The structure of foot-And-Mouth disease virus serotyp. To be published, .

Date:

02-Dec-09 Release date: 08-Dec-10

Protein chain

Q6PMU1  (Q6PMU1_9PICO) -  Genome polyprotein from Foot-and-mouth disease virus SAT 1

Seq: 2339 a.a.

Struc: 194 a.a.

Protein chain

Q6PMU1  (Q6PMU1_9PICO) -  Genome polyprotein from Foot-and-mouth disease virus SAT 1

Seq: 2339 a.a.

Struc: 207 a.a.

Protein chain

Q6PMU1  (Q6PMU1_9PICO) -  Genome polyprotein from Foot-and-mouth disease virus SAT 1

Seq: 2339 a.a.

Struc: 221 a.a.*

Protein chain

Q6PMU1  (Q6PMU1_9PICO) -  Genome polyprotein from Foot-and-mouth disease virus SAT 1

Seq: 2339 a.a.

Struc: 47 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class 1: Chains 1, 2, 3, 4: E.C.3.4.22.46 - L-peptidase.
• Reaction: Autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-|-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-|-Arg- and -Lys-|-Arg-.
• Enzyme class 2: Chains 1, 2, 3, 4: E.C.3.6.1.15 - nucleoside-triphosphate phosphatase.
• Reaction: a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H⁺

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site