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PDBsum entry 2w3a
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protein ligands Protein-protein interface(s) links
Oxidoreductase PDB id
2w3a

 

 

 

 

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Contents
Protein chain
186 a.a. *
Ligands
GOL ×2
NDP ×2
SO4
TOP ×2
Waters ×408
* Residue conservation analysis
PDB id:
2w3a
Name: Oxidoreductase
Title: Human dihydrofolate reductase complexed with NADPH and trimethoprim
Structure: Dihydrofolate reductase. Chain: a, b. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
1.50Å     R-factor:   0.181     R-free:   0.214
Authors: A.K.W.Leung,R.C.Reynolds,D.W.Borhani
Key ref: A.K.W.Leung et al. Structural basis for selective inhibition of mycobacterium avium dihydrofolate reductase by a lipophilic antifolate. To be published, .
Date:
10-Nov-08     Release date:   17-Nov-09    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P00374  (DYR_HUMAN) -  Dihydrofolate reductase from Homo sapiens
Seq:
Struc: 		187 a.a.
186 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.1.5.1.3  - dihydrofolate reductase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway: 		Folate Coenzymes
      Reaction: (6S)-5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
(6S)-5,6,7,8-tetrahydrofolate
 +
NADP(+)
Bound ligand (Het Group name = NDP)
corresponds exactly 		= 7,8-dihydrofolate
 + NADPH
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

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