PDBsum entry 2vux

Oxidoreductase

PDB id: 2vux

Contents

Protein chains

272 a.a. *

255 a.a. *

Metals

_FE ×2

* Residue conservation analysis

PDB id:

2vux

Name:

Oxidoreductase

Title:

Human ribonucleotide reductase, subunit m2 b

Structure:

Ribonucleoside-diphosphate reductase subunit m2 b. Chain: a, b. Fragment: residues 20-322. Synonym: tp53-inducible ribonucleotide reductase m2 b, p53-inducible ribonucleotide reductase small subunit 2-like protein, p53r2. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.80Å R-factor: 0.213 R-free: 0.258

Authors:

M.Welin,M.Moche,J.Andersson,C.H.Arrowsmith,H.Berglund,R.D.Busam, R.Collins,L.G.Dahlgren,A.M.Edwards,S.Flodin,A.Flores,S.Graslund, M.Hammarstrom,M.D.Herman,A.Johansson,I.Johansson,A.Kallas, T.Karlberg,T.Kotenyova,L.Lehtio,M.E.Nilsson,T.Nyman,C.Persson, J.Sagemark,H.Schueler,L.Svensson,A.G.Thorsell,L.Tresaugues,S.Van Den Berg,J.Weigelt,M.Wikstrom,P.Nordlund,Structural Genomics Consortium (Sgc)

Key ref:

M.Welin et al. Human ribonucleotide reductase, Subunit m2 b. To be published, .

Date:

31-May-08 Release date: 15-Jul-08

Protein chain

Q7LG56  (RIR2B_HUMAN) -  Ribonucleoside-diphosphate reductase subunit M2 B from Homo sapiens

Seq: 351 a.a.

Struc: 272 a.a.

Protein chain

Q7LG56  (RIR2B_HUMAN) -  Ribonucleoside-diphosphate reductase subunit M2 B from Homo sapiens

Seq: 351 a.a.

Struc: 255 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.1.17.4.1 - ribonucleoside-diphosphate reductase.
• Reaction: a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol
• Cofactor: Fe(3+) or adenosylcob(III)alamin or Mn(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site