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PDBsum entry 2vr2
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Contents |
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* Residue conservation analysis
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PDB id:
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Hydrolase
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Title:
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Human dihydropyrimidinase
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Structure:
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Dihydropyrimidinase. Chain: a. Synonym: dhpase, dhp, dihydropyrimidine amidohydrolase, hydantoinase. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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2.80Å
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R-factor:
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0.203
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R-free:
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0.251
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Authors:
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M.Welin,T.Karlberg,J.Andersson,C.H.Arrowsmith,H.Berglund,R.D.Busam, R.Collins,L.G.Dahlgren,A.M.Edwards,S.Flodin,A.Flores,S.Graslund, M.Hammarstrom,M.D.Herman,I.Johansson,A.Kallas,T.Kotenyova,L.Lehtio, M.Moche,M.E.Nilsson,T.Nyman,C.Persson,J.Sagemark,L.Svensson, A.G.Thorsell,L.Tresaugues,S.Van Den Berg,J.Weigelt,M.Wikstrom, P.Nordlund,Structural Genomics Consortium (Sgc)
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Key ref:
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M.Welin
et al.
The crystal structure of human dihydropyrimidinase.
To be published,
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Date:
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25-Mar-08
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Release date:
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01-Apr-08
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PROCHECK
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Headers
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References
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Q14117
(DPYS_HUMAN) -
Dihydropyrimidinase from Homo sapiens
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Seq:
Struc:
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519 a.a.
478 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.3.5.2.2
- dihydropyrimidinase.
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Reaction:
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5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H+
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5,6-dihydrouracil
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+
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H2O
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=
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3-(carbamoylamino)propanoate
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
