PDBsum entry 2vq6

Hydrolase

PDB id: 2vq6

Contents

Protein chain

529 a.a. *

Ligands

FP1

SO4

NAG ×2

Waters ×93

* Residue conservation analysis

PDB id:

2vq6

Name:

Hydrolase

Title:

Torpedo californica acetylcholinesterase complexed with 2-pam

Structure:

Acetylcholinesterase. Chain: a. Fragment: residues 22-464. Synonym: ache. Other_details: 2-formyl-1-methyl-pyridinium chloride (pralydoxime, 2- pam) in active site gorge

Source:

Torpedo californica. Pacific electric ray. Organism_taxid: 7787

Resolution:

2.71Å R-factor: 0.174 R-free: 0.234

Authors:

M.Harel,I.Silman,J.L.Sussman

Key ref:

M.Harel et al. The structure of torpedo californica acetylcholinesterase complexed with 2-Pam. To be published, .

Date:

11-Mar-08 Release date: 13-May-08

Supersedes:

2vb4

Protein chain

P04058  (ACES_TETCF) -  Acetylcholinesterase from Tetronarce californica

Seq: 586 a.a.

Struc: 529 a.a.

Enzyme reactions

• Enzyme class: E.C.3.1.1.7 - acetylcholinesterase.
• Reaction: acetylcholine + H2O = choline + acetate + H⁺

acetylcholine (Bound ligand (Het Group name = NAG) matches with 41.18% similarity) + H2O = choline + acetate (Bound ligand (Het Group name = FP1) matches with 41.67% similarity) + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site