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PDBsum entry 2vm6
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Immune system
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PDB id
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2vm6
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Contents |
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* Residue conservation analysis
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PDB id:
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Immune system
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Title:
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Human bcl2-a1 in complex with bim-bh3 peptide
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Structure:
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Bcl-2-related protein a1. Chain: a. Fragment: residues 1-149. Synonym: protein bfl-1, hemopoietic-specific early response protein, protein grs, bcl-2a1, a1. Engineered: yes. Bcl-2-like protein 11. Chain: b. Fragment: residues 141-165.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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2.20Å
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R-factor:
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0.196
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R-free:
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0.250
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Authors:
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M.D.Herman,L.Lehtio,C.H.Arrowsmith,H.Berglund,R.D.Busam,R.Collins, L.G.Dahlgren,A.M.Edwards,S.Flodin,A.Flores,S.Graslund,M.Hammarstrom, I.Johansson,A.Kallas,T.Karlberg,T.Kotenyova,M.Moche,M.E.Nilsson, T.Nyman,C.Persson,J.Sagemark,L.Svensson,A.G.Thorsell,L.Tresaugues, S.Van Den Berg,J.Weigelt,M.Welin,P.Nordlund,Structural Genomics Consortium (Sgc)
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Key ref:
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M.D.Herman
et al.
(2008).
Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim.
Febs Lett,
582,
3590-3594.
PubMed id:
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Date:
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23-Jan-08
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Release date:
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05-Feb-08
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PROCHECK
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Headers
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References
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Enzyme class:
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Chains A, B:
E.C.?
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Febs Lett
582:3590-3594
(2008)
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PubMed id:
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Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim.
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M.D.Herman,
T.Nyman,
M.Welin,
L.Lehtiö,
S.Flodin,
L.Trésaugues,
T.Kotenyova,
A.Flores,
P.Nordlund.
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ABSTRACT
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Evasion of apoptosis is recognized as a characteristic of malignant growth.
Anti-apoptotic B-cell lymphoma-2 (Bcl-2) family members have therefore emerged
as potential therapeutic targets due to their critical role in proliferating
cancer cells. Here, we present the crystal structure of Bfl-1, the last
anti-apoptotic Bcl-2 family member to be structurally characterized, in complex
with a peptide corresponding to the BH3 region of the pro-apoptotic protein Bim.
The structure reveals distinct features at the peptide-binding site, likely to
define the binding specificity for pro-apoptotic proteins. Superposition of the
Bfl-1:Bim complex with that of Mcl-1:Bim reveals a significant local plasticity
of hydrophobic interactions contributed by the Bim peptide, likely to be the
basis for the multi specificity of Bim for anti-apoptotic proteins.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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E.Fire,
S.V.Gullá,
R.A.Grant,
and
A.E.Keating
(2010).
Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes.
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Protein Sci,
19,
507-519.
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PDB codes:
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S.Dutta,
S.Gullá,
T.S.Chen,
E.Fire,
R.A.Grant,
and
A.E.Keating
(2010).
Determinants of BH3 binding specificity for Mcl-1 versus Bcl-xL.
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J Mol Biol,
398,
747-762.
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PDB code:
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M.J.Allday
(2009).
How does Epstein-Barr virus (EBV) complement the activation of Myc in the pathogenesis of Burkitt's lymphoma?
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Semin Cancer Biol,
19,
366-376.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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Links
