PDBsum entry 2vb4

Hydrolase

PDB id: 2vb4

Contents

Protein chain

529 a.a. *

Ligands

FP1

SO4

NAG ×2

Waters ×93

* Residue conservation analysis

Obsolete entry

PDB id:

2vb4

Name:

Hydrolase

Title:

Torpedo californica acetylcholinesterase complexed with 2- pam

Structure:

Acetylcholinesterase. Synonym: ache. Chain: a. Other_details: 2-formyl-1-methyl-pyridinium chloride ( pralydoxime, 2-pam) in active site gorge

Source:

Torpedo californica. Pacific electric ray

Resolution:

2.71Å R-factor: 0.174 R-free: 0.233

Authors:

M.Harel,I.Silman,J.L.Sussman

Key ref:

M.Harel et al. The structure of torpedo californica acetylcholinesterase complexed with 2-Pam. To be published, .

Date:

06-Sep-07 Release date: 18-Sep-07

Protein chain

P04058  (ACES_TETCF) -  Acetylcholinesterase from Tetronarce californica

Seq: 586 a.a.

Struc: 529 a.a.

Enzyme reactions

• Enzyme class: E.C.3.1.1.7 - acetylcholinesterase.
• Reaction: acetylcholine + H2O = choline + acetate + H⁺

acetylcholine (Bound ligand (Het Group name = NAG) matches with 41.18% similarity) + H2O = choline (Bound ligand (Het Group name = FP1) matches with 41.67% similarity) + acetate + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site