PDBsum entry 2uw2

Oxidoreductase

PDB id: 2uw2

Contents

Protein chain

275 a.a. *

Metals

_FE

Waters ×6

* Residue conservation analysis

PDB id:

2uw2

Name:

Oxidoreductase

Title:

Crystal structure of human ribonucleotide reductase subunit r2

Structure:

Ribonucleoside-diphosphate reductase m2 subunit. Chain: a. Fragment: residues 60-389. Synonym: ribonucleotide reductase small subunit, ribonucleotide reductase small chain, ribonucleotide reductase subunit r2. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.80Å R-factor: 0.233 R-free: 0.294

Authors:

M.Welin,D.Ogg,C.Arrowsmith,H.Berglund,R.Busam,R.Collins,A.Edwards, M.Ehn,S.Flodin,A.Flores,S.Graslund,M.Hammarstrom,B.M.Hallberg, L.Holmberg Schiavone,M.Hogbom,T.Kotenyova,A.Magnusdottir,M.Moche, P.Nilsson-Ehle,T.Nyman,C.Persson,J.Sagemark,M.Sundstrom,P.Stenmark, J.Uppenberg,A.G.Thorsell,S.Van Den Berg,K.Wallden,J.Weigelt, P.Nordlund

Key ref:

M.Welin et al. Crystal structure of human ribonucleotide reductase subunit r2. To be published, .

Date:

16-Mar-07 Release date: 03-Apr-07

Supersedes:

2iyh

Protein chain

P31350  (RIR2_HUMAN) -  Ribonucleoside-diphosphate reductase subunit M2 from Homo sapiens

Seq: 389 a.a.

Struc: 275 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.1.17.4.1 - ribonucleoside-diphosphate reductase.
• Reaction: a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol
• Cofactor: Fe(3+) or adenosylcob(III)alamin or Mn(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site