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PDBsum entry 2sbl
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protein metals Protein-protein interface(s) links
Oxidoreductase PDB id
2sbl

 

 

 

 

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Contents
Protein chains
807 a.a. *
Metals
_FE ×2
Waters ×63
* Residue conservation analysis
PDB id:
2sbl
Name: Oxidoreductase
Title: The three-dimensional structure of an arachidonic acid 15-lipoxygenase
Structure: Lipoxygenase-1. Chain: b, a. Engineered: yes
Source: Glycine max. Soybean. Organism_taxid: 3847
Resolution:
2.60Å     R-factor:   0.173    
Authors: L.M.Amzel,J.C.Boyington
Key ref: J.C.Boyington et al. (1993). The three-dimensional structure of an arachidonic acid 15-lipoxygenase. Science, 260, 1482-1486. PubMed id: 8502991 DOI: 10.1126/science.8502991
Date:
22-Jul-93     Release date:   27-Feb-95    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P08170  (LOX1_SOYBN) -  Seed linoleate 13S-lipoxygenase-1 from Glycine max
Seq:
Struc: 		 
Seq:
Struc: 		839 a.a.
807 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.1.13.11.12  - linoleate 13S-lipoxygenase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction:
1. (9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)- octadecadienoate
2. (9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)- octadecatrienoate
(9Z,12Z)-octadecadienoate
 + O2
 = (13S)-hydroperoxy-(9Z,11E)- octadecadienoate
(9Z,12Z,15Z)-octadecatrienoate
 + O2
 = (13S)-hydroperoxy-(9Z,11E,15Z)- octadecatrienoate
      Cofactor: Fe cation
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    Added reference    
 
 
DOI no: 10.1126/science.8502991 Science 260:1482-1486 (1993)
PubMed id: 8502991  
 
 
The three-dimensional structure of an arachidonic acid 15-lipoxygenase.
J.C.Boyington, B.J.Gaffney, L.M.Amzel.
 
  ABSTRACT  
 
In mammals, the hydroperoxidation of arachidonic acid by lipoxygenases leads to the formation of leukotrienes and lipoxins, compounds that mediate inflammatory responses. Lipoxygenases are dioxygenases that contain a nonheme iron and are present in many animal cells. Soybean lipoxygenase-1 is a single-chain, 839-residue protein closely related to mammalian lipoxygenases. The structure of soybean lipoxygenase-1 solved to 2.6 angstrom resolution shows that the enzyme has two domains: a 146-residue beta barrel and a 693-residue helical bundle. The iron atom is in the center of the larger domain and is coordinated by three histidines and the COO- of the carboxyl terminus. The coordination geometry is nonregular and appears to be a distorted octahedron in which two adjacent positions are not occupied by ligands. Two cavities, in the shapes of a bent cylinder and a frustum, connect the unoccupied positions to the surface of the enzyme. The iron, with two adjacent and unoccupied positions, is poised to interact with the 1,4-diene system of the substrate and with molecular oxygen during catalysis.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21257189 L.E.Chohany, K.A.Bishop, H.Camic, S.J.Sup, P.M.Findeis, and C.H.Clapp (2011).
Cationic substrates of soybean lipoxygenase-1.
  Bioorg Chem, 39, 94.  
21474321 L.Zoia, R.Perazzini, C.Crestini, and D.S.Argyropoulos (2011).
Understanding the radical mechanism of lipoxygenases using 31P NMR spin trapping.
  Bioorg Med Chem, 19, 3022-3028.  
20422083 F.Mei, C.Ou, G.Wu, L.Cao, F.Han, X.Meng, J.Li, D.Li, and Z.Liao (2010).
Non-heme iron(II/III) complexes that model the reactivity of lipoxygenase with a redox switch.
  Dalton Trans, 39, 4267-4269.  
20020224 Y.Cai, H.Xu, Y.Xia, Y.Su, and Y.Fang (2010).
A proof for substitution of endogenous iron (II) in lipoxygenase by exogenous Cu2+.
  Appl Biochem Biotechnol, 162, 1147-1152.  
20349083 Y.S.Park, S.Kunze, X.Ni, I.Feussner, and M.V.Kolomiets (2010).
Comparative molecular and biochemical characterization of segmentally duplicated 9-lipoxygenase genes ZmLOX4 and ZmLOX5 of maize.
  Planta, 231, 1425-1437.  
20354595 J.P.Klinman (2009).
An integrated model for enzyme catalysis emerges from studies of hydrogen tunneling.
  Chem Phys Lett, 471, 179-193.  
19683507 J.Rapp, S.Xu, A.M.Sharp, W.P.Griffith, Y.W.Kim, and M.O.Funk (2009).
EPR spectroscopy and electrospray ionization mass spectrometry reveal distinctive features of the iron site in leukocyte 12-lipoxygenase.
  Arch Biochem Biophys, 490, 50-56.  
18226602 A.Gamliel, M.Afri, and A.A.Frimer (2008).
Determining radical penetration of lipid bilayers with new lipophilic spin traps.
  Free Radic Biol Med, 44, 1394-1405.  
17879349 A.M.Peariso, K.M.Nicholson, R.Benjamin Jones, K.B.Green-Church, and M.O.Funk (2008).
Electrospray ionization mass spectrometry of soybean lipoxygenases: N-terminal acetylation, chemical modification, and solution conformation.
  Proteins, 70, 650-658.  
18972057 C.Jacquot, C.M.McGinley, E.Plata, T.R.Holman, and W.A.van der Donk (2008).
Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases.
  Org Biomol Chem, 6, 4242-4252.  
18502867 M.J.Moonen, S.A.Synowsky, W.A.van den Berg, A.H.Westphal, A.J.Heck, R.H.van den Heuvel, M.W.Fraaije, and W.J.van Berkel (2008).
Hydroquinone dioxygenase from pseudomonas fluorescens ACB: a novel member of the family of nonheme-iron(II)-dependent dioxygenases.
  J Bacteriol, 190, 5199-5209.  
18656914 R.Sarangi, R.K.Hocking, M.L.Neidig, M.Benfatto, T.R.Holman, E.I.Solomon, K.O.Hodgson, and B.Hedman (2008).
Geometric structure determination of N694C lipoxygenase: a comparative near-edge X-ray absorption spectroscopy and extended X-ray absorption fine structure study.
  Inorg Chem, 47, 11543-11550.  
17524979 C.Schneider, D.A.Pratt, N.A.Porter, and A.R.Brash (2007).
Control of oxygenation in lipoxygenase and cyclooxygenase catalysis.
  Chem Biol, 14, 473-488.  
17675410 J.Saam, I.Ivanov, M.Walther, H.G.Holzhütter, and H.Kuhn (2007).
Molecular dioxygen enters the active site of 12/15-lipoxygenase via dynamic oxygen access channels.
  Proc Natl Acad Sci U S A, 104, 13319-13324.  
17523638 M.L.Neidig, A.T.Wecksler, G.Schenk, T.R.Holman, and E.I.Solomon (2007).
Kinetic and spectroscopic studies of N694C lipoxygenase: a probe of the substrate activation mechanism of a nonheme ferric enzyme.
  J Am Chem Soc, 129, 7531-7537.  
18003930 M.Y.Pau, J.D.Lipscomb, and E.I.Solomon (2007).
Substrate activation for O2 reactions by oxidized metal centers in biology.
  Proc Natl Acad Sci U S A, 104, 18355-18362.  
17712823 S.Vandevoorde, and D.M.Lambert (2007).
The multiple pathways of endocannabinoid metabolism: a zoom out.
  Chem Biodivers, 4, 1858-1881.  
17022084 B.Youn, G.E.Sellhorn, R.J.Mirchel, B.J.Gaffney, H.D.Grimes, and C.Kang (2006).
Crystal structures of vegetative soybean lipoxygenase VLX-B and VLX-D, and comparisons with seed isoforms LOX-1 and LOX-3.
  Proteins, 65, 1008-1020.
PDB codes: 2iuj 2iuk
16790932 E.Skrzypczak-Jankun, O.Y.Borbulevych, M.I.Zavodszky, M.R.Baranski, K.Padmanabhan, V.Petricek, and J.Jankun (2006).
Effect of crystal freezing and small-molecule binding on internal cavity size in a large protein: X-ray and docking studies of lipoxygenase at ambient and low temperature at 2.0 A resolution.
  Acta Crystallogr D Biol Crystallogr, 62, 766-775.
PDB codes: 1rrh 1rrl
17029406 F.Wu, and B.J.Gaffney (2006).
Dynamic behavior of fatty acid spin labels within a binding site of soybean lipoxygenase-1.
  Biochemistry, 45, 12510-12518.  
17088625 J.M.McClain, D.L.Maples, R.D.Maples, D.L.Matz, S.M.Harris, A.D.Nelson, J.D.Silversides, S.J.Archibald, and T.J.Hubin (2006).
Dichloro(4,10-dimethyl-1,4,7,10-tetraazabicyclo[5.5.2]tetradecane)iron(III) hexafluorophosphate.
  Acta Crystallogr C, 62, m553-m555.  
16157595 G.Coffa, A.N.Imber, B.C.Maguire, G.Laxmikanthan, C.Schneider, B.J.Gaffney, and A.R.Brash (2005).
On the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant.
  J Biol Chem, 280, 38756-38766.  
16270276 H.Kühn, I.Römisch, and J.Belkner (2005).
The role of lipoxygenase-isoforms in atherogenesis.
  Mol Nutr Food Res, 49, 1014-1029.  
16317455 M.L.Neidig, and E.I.Solomon (2005).
Structure-function correlations in oxygen activating non-heme iron enzymes.
  Chem Commun (Camb), (), 5843-5863.  
14607519 D.Lapenna, G.Ciofani, S.D.Pierdomenico, M.A.Giamberardino, and F.Cuccurullo (2003).
Dihydrolipoic acid inhibits 15-lipoxygenase-dependent lipid peroxidation.
  Free Radic Biol Med, 35, 1203-1209.  
11939775 G.C.Ferreira, R.Franco, A.Mangravita, and G.N.George (2002).
Unraveling the substrate-metal binding site of ferrochelatase: an X-ray absorption spectroscopic study.
  Biochemistry, 41, 4809-4818.  
12106812 H.Kühn, and A.Borchert (2002).
Regulation of enzymatic lipid peroxidation: the interplay of peroxidizing and peroxide reducing enzymes.
  Free Radic Biol Med, 33, 154-172.  
12047377 L.Hörnsten, C.Su, A.E.Osbourn, U.Hellman, and E.H.Oliw (2002).
Cloning of the manganese lipoxygenase gene reveals homology with the lipoxygenase gene family.
  Eur J Biochem, 269, 2690-2697.  
11231304 G.Mita, A.Gallo, V.Greco, C.Zasiura, R.Casey, G.Zacheo, and A.Santino (2001).
Molecular cloning and biochemical characterization of a lipoxygenase in almond (Prunus dulcis) seed.
  Eur J Biochem, 268, 1500-1507.  
11389595 M.Maccarrone, M.L.Salucci, G.van Zadelhoff, F.Malatesta, G.Veldink, J.F.Vliegenthart, and A.Finazzi-Agrò (2001).
Tryptic digestion of soybean lipoxygenase-1 generates a 60 kDa fragment with improved activity and membrane binding ability.
  Biochemistry, 40, 6819-6827.  
11514227 M.Walther, I.Ivanov, G.Myagkova, and H.Kuhn (2001).
Alterations of lipoxygenase specificity by targeted substrate modification and site-directed mutagenesis.
  Chem Biol, 8, 779-790.  
11371199 T.Hammarberg, S.Kuprin, O.Rådmark, and A.Holmgren (2001).
EPR investigation of the active site of recombinant human 5-lipoxygenase: inhibition by selenide.
  Biochemistry, 40, 6371-6378.  
11151005 U.Dengler, A.S.Siddiqui, and G.J.Barton (2001).
Protein structural domains: analysis of the 3Dee domains database.
  Proteins, 42, 332-344.  
10704209 C.H.Clapp, J.McKown, H.Xu, A.M.Grandizio, G.Yang, and J.Fayer (2000).
The action of soybean lipoxygenase-1 on 12-iodo-cis-9-octadecenoic acid: the importance of C11-H bond breaking.
  Biochemistry, 39, 2603-2611.  
10672019 C.May, M.Höhne, P.Gnau, K.Schwennesen, and H.Kindl (2000).
The N-terminal beta-barrel structure of lipid body lipoxygenase mediates its binding to liposomes and lipid bodies.
  Eur J Biochem, 267, 1100-1109.  
11004552 E.Sudharshan, S.Srinivasulu, and A.G.Appu Rao (2000).
pH-induced domain interaction and conformational transitions of lipoxygenase-1.
  Biochim Biophys Acta, 1480, 13-22.  
11076513 K.H.Lee, D.R.Benson, and K.Kuczera (2000).
Transitions from alpha to pi helix observed in molecular dynamics simulations of synthetic peptides.
  Biochemistry, 39, 13737-13747.  
10760478 S.Tornhamre, A.Elmqvist, and J.A.Lindgren (2000).
15-Lipoxygenation of leukotriene A(4). Studies Of 12- and 15-lipoxygenase efficiency to catalyze lipoxin formation.
  Biochim Biophys Acta, 1484, 298-306.  
  10739264 T.M.Weaver (2000).
The pi-helix translates structure into function.
  Protein Sci, 9, 201-206.  
10368270 A.Kita, S.Kita, I.Fujisawa, K.Inaka, T.Ishida, K.Horiike, M.Nozaki, and K.Miki (1999).
An archetypical extradiol-cleaving catecholic dioxygenase: the crystal structure of catechol 2,3-dioxygenase (metapyrocatechase) from Ppseudomonas putida mt-2.
  Structure, 7, 25-34.
PDB code: 1mpy
10607676 C.J.Schofield, and Z.Zhang (1999).
Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes.
  Curr Opin Struct Biol, 9, 722-731.  
16429610 C.R.Bowers, V.Storhaug, C.E.Webster, J.Bharatam, A.Cottone, R.Gianna, K.Betsey, and B.J.Gaffney (1999).
Exploring surfaces and cavities in lipoxygenase and other proteins by hyperpolarized xenon-129 NMR.
  J Am Chem Soc, 121, 9370-9377.  
10570245 H.van Tilbeurgh, S.Bezzine, C.Cambillau, R.Verger, and F.Carrière (1999).
Colipase: structure and interaction with pancreatic lipase.
  Biochim Biophys Acta, 1441, 173-184.  
9634695 B.Kauppi, K.Lee, E.Carredano, R.E.Parales, D.T.Gibson, H.Eklund, and S.Ramaswamy (1998).
Structure of an aromatic-ring-hydroxylating dioxygenase-naphthalene 1,2-dioxygenase.
  Structure, 6, 571-586.
PDB code: 1ndo
9922163 C.Pham, J.Jankun, E.Skrzypczak-Jankun, R.A.Flowers, and M.O.Funk (1998).
Structural and thermochemical characterization of lipoxygenase-catechol complexes.
  Biochemistry, 37, 17952-17957.
PDB code: 1byt
9764311 E.Blée (1998).
Phytooxylipins and plant defense reactions.
  Prog Lipid Res, 37, 33-72.  
9748316 J.Hendriks, A.Warne, U.Gohlke, T.Haltia, C.Ludovici, M.Lübben, and M.Saraste (1998).
The active site of the bacterial nitric oxide reductase is a dinuclear iron center.
  Biochemistry, 37, 13102-13109.  
9636068 J.Neuzil, J.M.Upston, P.K.Witting, K.F.Scott, and R.Stocker (1998).
Secretory phospholipase A2 and lipoprotein lipase enhance 15-lipoxygenase-induced enzymic and nonenzymic lipid peroxidation in low-density lipoproteins.
  Biochemistry, 37, 9203-9210.  
9399878 K.N.Degtyarenko, A.C.North, D.N.Perkins, and J.B.Findlay (1998).
PROMISE: a database of information on prosthetic centres and metal ions in protein active sites.
  Nucleic Acids Res, 26, 376-381.  
9799493 K.Schwarz, S.Borngräber, M.Anton, and H.Kuhn (1998).
Probing the substrate alignment at the active site of 15-lipoxygenases by targeted substrate modification and site-directed mutagenesis. Evidence for an inverse substrate orientation.
  Biochemistry, 37, 15327-15335.  
9799511 S.A.Tatulian, J.Steczko, and W.Minor (1998).
Uncovering a calcium-regulated membrane-binding mechanism for soybean lipoxygenase-1.
  Biochemistry, 37, 15481-15490.  
9501907 S.T.Prigge, B.J.Gaffney, and L.M.Amzel (1998).
Relation between positional specificity and chirality in mammalian lipoxygenases.
  Nat Struct Biol, 5, 178-179.  
9159112 A.L.Pinto, H.W.Hellinga, and J.P.Caradonna (1997).
Construction of a catalytically active iron superoxide dismutase by rational protein design.
  Proc Natl Acad Sci U S A, 94, 5562-5567.  
9254600 A.M.Orville, J.D.Lipscomb, and D.H.Ohlendorf (1997).
Crystal structures of substrate and substrate analog complexes of protocatechuate 3,4-dioxygenase: endogenous Fe3+ ligand displacement in response to substrate binding.
  Biochemistry, 36, 10052-10066.
PDB codes: 3pca 3pcj 3pck 3pcl 3pcm
9177185 A.R.Brash, W.E.Boeglin, and M.S.Chang (1997).
Discovery of a second 15S-lipoxygenase in humans.
  Proc Natl Acad Sci U S A, 94, 6148-6152.  
9406540 C.D.Funk, and P.J.Loll (1997).
A molecular dipstick?
  Nat Struct Biol, 4, 966-968.  
9434907 C.J.Schofield, J.E.Baldwin, M.F.Byford, I.Clifton, J.Hajdu, C.Hensgens, and P.Roach (1997).
Proteins of the penicillin biosynthesis pathway.
  Curr Opin Struct Biol, 7, 857-864.  
9384534 E.I.Solomon, J.Zhou, F.Neese, and E.G.Pavel (1997).
New insights from spectroscopy into the structure/function relationships of lipoxygenases.
  Chem Biol, 4, 795-808.  
9182996 H.G.Holzhütter, R.Wiesner, J.Rathmann, R.Stösser, and H.Kühn (1997).
A kinetic model for the interaction of nitric oxide with a mammalian lipoxygenase.
  Eur J Biochem, 245, 608-616.  
8958130 J.Neuzil, S.R.Thomas, and R.Stocker (1997).
Requirement for, promotion, or inhibition by alpha-tocopherol of radical-induced initiation of plasma lipoprotein lipid peroxidation.
  Free Radic Biol Med, 22, 57-71.  
9406550 S.A.Gillmor, A.Villaseñor, R.Fletterick, E.Sigal, and M.F.Browner (1997).
The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity.
  Nat Struct Biol, 4, 1003-1009.
PDB codes: 1lox 1lp0 1lp2 1lp5
9373619 S.Yamamoto, H.Suzuki, and N.Ueda (1997).
Arachidonate 12-lipoxygenases.
  Prog Lipid Res, 36, 23-41.  
9109655 W.F.Nieuwenhuizen, A.Van der Kerk-Van Hoof, J.H.van Lenthe, R.C.Van Schaik, K.Versluis, G.A.Veldink, and J.F.Vliegenthart (1997).
Lipoxygenase is irreversibly inactivated by the hydroperoxides formed from the enynoic analogues of linoleic acid.
  Biochemistry, 36, 4480-4488.  
15012289 A.G.Prescott, and P.John (1996).
DIOXYGENASES: Molecular Structure and Role in Plant Metabolism.
  Annu Rev Plant Physiol Plant Mol Biol, 47, 245-271.  
8944751 C.D.Funk (1996).
The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice.
  Biochim Biophys Acta, 1304, 65-84.  
8951996 J.W.Kitzler, and T.E.Eling (1996).
Cloning, sequencing and expression of a 5-lipoxygenase from Syrian hamster embryo fibroblasts.
  Prostaglandins Leukot Essent Fatty Acids, 55, 269-277.  
8679612 M.Björnstedt, B.Odlander, S.Kuprin, H.E.Claesson, and A.Holmgren (1996).
Selenite incubated with NADPH and mammalian thioredoxin reductase yields selenide, which inhibits lipoxygenase and changes the electron spin resonance spectrum of the active site iron.
  Biochemistry, 35, 8511-8516.  
8841132 M.H.Glickman, and J.P.Klinman (1996).
Lipoxygenase reaction mechanism: demonstration that hydrogen abstraction from substrate precedes dioxygen binding during catalytic turnover.
  Biochemistry, 35, 12882-12892.  
8972456 M.Pérez-Gilabert, G.A.Veldink, and J.F.Vliegenthart (1996).
Protection by different agents against inactivation of lipoxygenase by hydrogen peroxide.
  Lipids, 31, 1245-1250.  
8718858 W.Minor, J.Steczko, B.Stec, Z.Otwinowski, J.T.Bolin, R.Walter, and B.Axelrod (1996).
Crystal structure of soybean lipoxygenase L-1 at 1.4 A resolution.
  Biochemistry, 35, 10687-10701.
PDB code: 1yge
7760687 C.Su, I.D.Brodowsky, and E.H.Oliw (1995).
Studies on linoleic acid 8R-dioxygenase and hydroperoxide isomerase of the fungus Gaeumannomyces graminis.
  Lipids, 30, 43-50.  
7579648 D.Shortle, and J.Sondek (1995).
The emerging role of insertions and deletions in protein engineering.
  Curr Opin Biotechnol, 6, 387-393.  
  7549886 J.Steczko, W.Minor, V.Stojanoff, and B.Axelrod (1995).
Crystallization and preliminary X-ray investigation of lipoxygenase-3 from soybeans.
  Protein Sci, 4, 1233-1235.  
  7642502 K.Ma, H.Loessner, J.Heider, M.K.Johnson, and M.W.Adams (1995).
Effects of elemental sulfur on the metabolism of the deep-sea hyperthermophilic archaeon Thermococcus strain ES-1: characterization of a sulfur-regulated, non-heme iron alcohol dehydrogenase.
  J Bacteriol, 177, 4748-4756.  
7475989 K.Matsui, and T.Kajiwara (1995).
Cucumber cotyledon lipoxygenase oxygenizes trilinolein at the lipid/water interface.
  Lipids, 30, 733-738.  
7492614 K.W.van Dijk, K.Steketee, L.Havekes, R.Frants, and M.Hofker (1995).
Genomic and cDNA cloning of a novel mouse lipoxygenase gene.
  Biochim Biophys Acta, 1259, 4-8.  
7628469 L.M.van der Heijdt, M.J.Schilstra, M.C.Feiters, H.F.Nolting, C.Hermes, G.A.Veldink, and J.F.Vliegenthart (1995).
Changes in the iron coordination sphere of Fe(II) lipoxygenase-1 from soybeans upon binding of linoleate or oleate.
  Eur J Biochem, 231, 186-191.  
7760688 M.Maccarrone, G.A.Veldink, J.F.Vliegenthart, and A.finnazzi Agrò (1995).
Inhibition of soybean lipoxygenase-1 by chain-breaking antioxidants.
  Lipids, 30, 51-54.  
8585333 O.Heinisch, E.Kowalski, K.Goossens, J.Frank, K.Heremans, H.Ludwig, and B.Tauscher (1995).
Pressure effects on the stability of lipoxygenase: Fourier transform-infrared spectroscopy (FT-IR) and enzyme activity studies.
  Z Lebensm Unters Forsch, 201, 562-565.  
7568029 R.Li, M.A.Bianchet, P.Talalay, and L.M.Amzel (1995).
The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction.
  Proc Natl Acad Sci U S A, 92, 8846-8850.
PDB code: 1qrd
7607208 T.Hammarberg, Y.Y.Zhang, B.Lind, O.Radmark, and B.Samuelsson (1995).
Mutations at the C-terminal isoleucine and other potential iron ligands of 5-lipoxygenase.
  Eur J Biochem, 230, 401-407.  
7712597 K.V.Honn, D.G.Tang, X.Gao, I.A.Butovich, B.Liu, J.Timar, and W.Hagmann (1994).
12-lipoxygenases and 12(S)-HETE: role in cancer metastasis.
  Cancer Metastasis Rev, 13, 365-396.  
7937731 L.Holm, and C.Sander (1994).
Searching protein structure databases has come of age.
  Proteins, 19, 165-173.  
7712291 M.J.Nelson, and S.P.Seitz (1994).
The structure and function of lipoxygenase.
  Curr Opin Struct Biol, 4, 878-884.  
8016074 W.H.Wang, T.Takano, D.Shibata, K.Kitamura, and G.Takeda (1994).
Molecular basis of a null mutation in soybean lipoxygenase 2: substitution of glutamine for an iron-ligand histidine.
  Proc Natl Acad Sci U S A, 91, 5828-5832.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.

 

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