PDBsum entry 2r1v

Protein binding

PDB id: 2r1v

Contents

Protein chain

187 a.a. *

Waters ×433

* Residue conservation analysis

PDB id:

2r1v

Name:

Protein binding

Title:

Norepinephrine quinone conjugation to dj-1

Structure:

Dj-1. Chain: a. Synonym: oncogene dj1, parkinson disease protein 7. Engineered: yes. Mutation: yes. Dj-1. Chain: b. Synonym: oncogene dj1, parkinson disease protein 7. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: park7. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.70Å R-factor: 0.181 R-free: 0.202

Authors:

Z.Zhongtao,F.Yue

Key ref:

Z.Zhongtao and f.yue Dj-1 activation by catechol quinone conjugation. To be published, .

Date:

23-Aug-07 Release date: 26-Aug-08

Protein chains

Q99497  (PARK7_HUMAN) -  Parkinson disease protein 7 from Homo sapiens

Seq: 189 a.a.

Struc: 187 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.5.1.124 - protein deglycase.
• Reaction:
  1. N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] + H2O = lactate + L-arginyl-[protein] + H⁺
  2. N₆-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] + H2O = lactate + L-lysyl-[protein] + H⁺
  3. S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] + H2O = lactate + L-cysteinyl-[protein] + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site