PDBsum entry 2qm3

Transferase

PDB id

2qm3

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Contents

			Protein chain

					338 a.a. *

			Ligands

					ACY ×3

			Metals

					_CA ×2

			Waters ×223

* Residue conservation analysis

PDB id:

2qm3

Links

Name:

Transferase

Title:

Crystal structure of a predicted methyltransferase from pyrococcus furiosus

Structure:

Predicted methyltransferase. Chain: a. Synonym: uncharacterized protein pf1111. Engineered: yes

Source:

Pyrococcus furiosus dsm 3638. Organism_taxid: 186497. Strain: dsm 3638, jcm 8422, vc1. Atcc: 43587. Gene: pf1111. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

2.05Å

R-factor:

0.185

R-free:

0.227

Authors:

M.E.Cuff,E.Duggan,S.Clancy,A.Joachimiak,Midwest Center For Structural Genomics (Mcsg)

Key ref:

M.E.Cuff et al. The structure of a predicted methyltransferase from pyrococcus furiosus.. To be published, .

Date:

13-Jul-07

Release date:

11-Sep-07

PROCHECK

	Headers

	References

Protein chain

Q8U1U4 (Q8U1U4_PYRFU) - N(4)-bis(aminopropyl)spermidine synthase from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

Seq: Struc:					349 a.a. 338 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

E.C.2.5.1.128 - N(4)-bis(aminopropyl)spermidine synthase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = N₄- bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine + 2 H⁺

2 × S-adenosyl 3-(methylsulfanyl)propylamine	+	spermidine	=	N(4)- bis(aminopropyl)spermidine	+	2 × S-methyl-5'-thioadenosine	+	2 × H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site