PDBsum entry 2px7

Transferase

PDB id: 2px7

Contents

Protein chains

203 a.a. *

Waters ×160

* Residue conservation analysis

PDB id:

2px7

Name:

Transferase

Title:

Crystal structure of 2-c-methyl-d-erythritol 4-phosphate cytidylyltransferase from thermus thermophilus hb8

Structure:

2-c-methyl-d-erythritol 4-phosphate cytidylyltransferase. Chain: a, b. Synonym: 4-diphosphocytidyl-2c-methyl-d-erythritol synthase, mep cytidylyltransferase, mct. Engineered: yes

Source:

Thermus thermophilus hb8. Organism_taxid: 300852. Strain: hb8, dsm 579. Atcc: 27634. Gene: ispd, ttha0171. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.20Å R-factor: 0.228 R-free: 0.248

Authors:

L.Chen,M.Tsukuda,A.Ebihara,A.Shinkai,S.Kuramitsu,S.Yokoyama,L.- Q.Chen,Z.-J.Liu,D.Lee,S.-H.Chang,D.Nguyen,J.P.Rose,B.-C.Wang, Southeast Collaboratory For Structural Genomics (Secsg),Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

L.Chen et al. Crystal structure of 2-C-Methyl-D-Erythritol 4-Phosphate cytidylyltransferase from thermus thermophilus hb8.. To be published, .

Date:

14-May-07 Release date: 12-Jun-07

Protein chains

Q5SLX2  (ISPD_THET8) -  2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)

Seq: 213 a.a.

Struc: 203 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.7.60 - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase.
• Reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP + H⁺ = 4-CDP-2-C-methyl-D- erythritol + diphosphate
• Cofactor: Mn(2+) or Mg(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site