PDBsum entry 2ocs

Structural protein

PDB id: 2ocs

Contents

Protein chain

85 a.a. *

Ligands

SCN

EDO

Waters ×91

* Residue conservation analysis

PDB id:

2ocs

Name:

Structural protein

Title:

The crystal structure of the first pdz domain of human nherf-2 (slc9a3r2)

Structure:

Na(+)/h(+) exchange regulatory cofactor nhe-rf2. Chain: a. Synonym: nherf-2, tyrosine kinase activator protein 1, tka-1, sry- interacting protein 1, sip-1, solute carrier family 9 isoform a3 regulatory factor 2, nhe3 kinase a regulatory protein e3karp, sodium- hydrogen exchanger regulatory factor 2. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: slc9a3r2, nherf2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.50Å R-factor: 0.154 R-free: 0.198

Authors:

E.Papagrigoriou,C.Phillips,C.Gileadi,J.Elkins,E.Salah,G.Berridge, P.Savitsky,F.Gorrec,C.Umeano,E.Ugochukwu,O.Gileadi,N.Burgess, A.Edwards,C.H.Arrowsmith,J.Weigelt,M.Sundstrom,D.A.Doyle,Structural Genomics Consortium (Sgc)

Key ref:

E.Papagrigoriou et al. The crystal structure of the first pdz domain of human nherf-2 (slc9a3r2). To be published, .

Date:

21-Dec-06 Release date: 16-Jan-07

Protein chain

Q15599  (NHRF2_HUMAN) -  Na(+)/H(+) exchange regulatory cofactor NHE-RF2 from Homo sapiens

Seq: 337 a.a.

Struc: 85 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)