PDBsum entry 2o15

Transferase

PDB id: 2o15

Contents

Protein chain

424 a.a. *

Ligands

SO4

PO4 ×2

Waters ×173

* Residue conservation analysis

PDB id:

2o15

Name:

Transferase

Title:

Mycobacterium tuberculosis epsp synthase after partial products withdrawal

Structure:

3-phosphoshikimate 1-carboxyvinyltransferase. Chain: a. Synonym: 5-enolpyruvylshikimate-3-phosphate synthase, epsp synthase, epsps. Engineered: yes

Source:

Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: aroa. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.95Å R-factor: 0.209

Authors:

G.S.Kachalova,H.D.Bartunik,Mycobacterium Tuberculosis Structural Proteomics Project (Xmtb)

Key ref:

G.S.Kachalova et al. Complexes of 3-Phosphoshikimate 1-Carboxyvinyltransferase. To be published, .

Date:

28-Nov-06 Release date: 08-Apr-08

Protein chain

P9WPY5  (AROA_MYCTU) -  3-phosphoshikimate 1-carboxyvinyltransferase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Seq: 450 a.a.

Struc: 424 a.a.

Enzyme reactions

• Enzyme class: E.C.2.5.1.19 - 3-phosphoshikimate 1-carboxyvinyltransferase.
• Pathway: Shikimate and Chorismate Biosynthesis
• Reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3- phosphoshikimate + phosphate

3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3- phosphoshikimate + phosphate (Bound ligand (Het Group name = PO4) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site