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PDBsum entry 2nq3
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Contents |
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* Residue conservation analysis
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PDB id:
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Ligase
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Title:
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Crystal structure of the c2 domain of human itchy homolog e3 ubiquitin protein ligase
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Structure:
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Itchy homolog e3 ubiquitin protein ligase. Chain: a. Fragment: c2 domain. Synonym: itch, atrophin-1-interacting protein 4, aip4, nfe2- associated polypeptide 1, napp1. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: itch. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
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Resolution:
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1.80Å
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R-factor:
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0.164
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R-free:
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0.195
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Authors:
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J.R.Walker,G.V.Avvakumov,S.Xue,C.Butler-Cole,P.J.Finerty Jr., J.Weigelt,M.Sundstrom,C.H.Arrowsmith,A.M.Edwards,A.Bochkarev,S.Dhe- Paganon,Structural Genomics Consortium (Sgc)
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Key ref:
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J.R.Walker
et al.
The c2 domain of human itchy homolog e3 ubiquitin protein ligase.
To be published,
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Date:
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30-Oct-06
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Release date:
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14-Nov-06
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PROCHECK
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Headers
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References
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Q96J02
(ITCH_HUMAN) -
E3 ubiquitin-protein ligase Itchy homolog from Homo sapiens
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Seq:
Struc:
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903 a.a.
131 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.3.2.26
- HECT-type E3 ubiquitin transferase.
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Reaction:
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S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6- ubiquitinyl-[acceptor protein]-L-lysine
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Links
