PDBsum entry 2lyd

Transcription/protein binding

PDB id: 2lyd

Contents

Protein chains

134 a.a.

38 a.a.

PDB id:

2lyd

Name:

Transcription/protein binding

Title:

The solution structure of the dm dcp1 evh1 domain in complex with the xrn1 dbm peptide

Structure:

Decapping protein 1. Chain: a. Engineered: yes. Pacman protein. Chain: b. Engineered: yes

Source:

Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: dcp1, cg11183, dmel_cg11183. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: pcm, pacman, cg3291.

NMR struc:

21 models

Authors:

V.Truffault

Key ref:

J.E.Braun et al. (2012). A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation. Nat Struct Biol, 19, 1324-1331. PubMed id: 23142987

Date:

17-Sep-12 Release date: 17-Oct-12

Protein chain

Q9W1H5  (Q9W1H5_DROME) -  Decapping protein 1, isoform A from Drosophila melanogaster

Seq: 372 a.a.

Struc: 134 a.a.

Protein chain

E1JJR3  (E1JJR3_DROME) -  5'-3' exoribonuclease 1 from Drosophila melanogaster

Seq: 1613 a.a.

Struc: 38 a.a.*

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain B: E.C.3.1.13.- - ?????

Nat Struct Biol 19:1324-1331 (2012)

PubMed id: 23142987

A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation.

J.E.Braun, V.Truffault, A.Boland, E.Huntzinger, C.T.Chang, G.Haas, O.Weichenrieder, M.Coles, E.Izaurralde.

ABSTRACT

No abstract given.