PDBsum entry 2lfe

Ligase

PDB id: 2lfe

Contents

Protein chain

106 a.a.

PDB id:

2lfe

Name:

Ligase

Title:

Solution nmr structure of n-terminal domain of human e3 ubiquitin- protein ligase hecw2, northeast structural genomics consortium (nesg) target ht6306a

Structure:

E3 ubiquitin-protein ligase hecw2. Chain: a. Synonym: hect, c2 and ww domain-containing protein 2, nedd4-like e3 ubiquitin-protein ligase 2. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hecw2, kiaa1301, nedl2. Expressed in: escherichia coli. Expression_system_taxid: 562

NMR struc:

16 models

Authors:

A.Lemak,A.Yee,S.Houliston,M.Garcia,S.Chitayat,S.Dhe-Paganon, G.T.Montelione,C.Arrowsmith,Northeast Structural Genomics Consortium (Nesg),Structural Genomics Consortium (Sgc)

Key ref:

A.Lemak et al. Nmr solution structure of n-Terminal domain of e3 lig hecw2. To be published, .

Date:

29-Jun-11 Release date: 27-Jul-11

Protein chain

Q9P2P5  (HECW2_HUMAN) -  E3 ubiquitin-protein ligase HECW2 from Homo sapiens

Seq: 1572 a.a.

Struc: 106 a.a.

Enzyme reactions

• Enzyme class: E.C.2.3.2.26 - HECT-type E3 ubiquitin transferase.
• Reaction: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆- ubiquitinyl-[acceptor protein]-L-lysine