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PDBsum entry 2lcx
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PDB id:
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Transferase
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Title:
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Spatial structure of the erbb4 dimeric tm domain
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Structure:
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Receptor tyrosine-protein kinase erbb-4. Chain: a, b. Fragment: transmembrane residues 642-685. Synonym: proto-oncogene-like protein c-erbb-4, tyrosine kinase-type cell surface receptor her4, p180erbb4, erbb4 intracellular domain, 4icd, e4icd, s80her4. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb4, her4. Expressed in: escherichia coli. Expression_system_taxid: 562
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NMR struc:
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20 models
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Authors:
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K.S.Mineev,E.V.Bocharov,A.S.Arseniev
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Key ref:
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E.V.Bocharov
et al.
(2012).
Structural and thermodynamic insight into the process of "weak" dimerization of the ErbB4 transmembrane domain by solution NMR.
Biochim Biophys Acta,
1818,
2158-2170.
PubMed id:
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Date:
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11-May-11
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Release date:
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16-May-12
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PROCHECK
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Headers
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References
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Q15303
(ERBB4_HUMAN) -
Receptor tyrosine-protein kinase erbB-4 from Homo sapiens
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Seq:
Struc:
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1308 a.a.
44 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class:
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E.C.2.7.10.1
- receptor protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Biochim Biophys Acta
1818:2158-2170
(2012)
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PubMed id:
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Structural and thermodynamic insight into the process of "weak" dimerization of the ErbB4 transmembrane domain by solution NMR.
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E.V.Bocharov,
K.S.Mineev,
M.V.Goncharuk,
A.S.Arseniev.
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ABSTRACT
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