PDBsum entry 2l3c

Hydrolase/RNA

PDB id

2l3c

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Contents

			Protein chain

					74 a.a. *

			DNA/RNA

* Residue conservation analysis

PDB id:

2l3c

Links
- PDBe
- RCSB
- MMDB
- JenaLib
- Proteopedia
- CATH
- SCOP
- PDBSWS
- ProSAT

Name:

Hydrolase/RNA

Title:

Solution structure of adar2 dsrbm1 bound to lsl RNA

Structure:

Double-stranded RNA-specific editase 1. Chain: a. Fragment: unp residues 74-147. Synonym: dsrna adenosine deaminase, RNA-editing deaminase 1, RNA- editing enzyme 1. Engineered: yes. RNA (34-mer). Chain: b. Engineered: yes

Source:

Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: adarb1, red1. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562

NMR struc:

20 models

Authors:

F.Allain,R.Stefl,F.Oberstrass

Key ref:

R.Stefl et al. (2010). The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific readout of the minor groove. Cell, 143, 225-237. PubMed id: 20946981

Date:

12-Sep-10

Release date:

27-Oct-10

PROCHECK

	Headers

	References

Protein chain

P51400 (RED1_RAT) - Double-stranded RNA-specific editase 1 from Rattus norvegicus

Seq: Struc:

Seq: Struc:					711 a.a. 74 a.a.

Key:

PfamA domain

Secondary structure

CATH domain

DNA/RNA chain

G-G-U-A-G-U-A-U-A-A-C-A-A-U-A-U-C-C-G-U-G-U-U-G-U-U-A-U-A-G-U-A-C-C 34 bases



		Enzyme reactions

Enzyme class:

E.C.3.5.4.37 - double-stranded Rna adenine deaminase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

adenosine in double-stranded RNA + H2O + H⁺ = inosine in double- stranded RNA + NH4⁺

	Cell 143:225-237 (2010)
PubMed id: 20946981

The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific readout of the minor groove.
R.Stefl, F.C.Oberstrass, J.L.Hood, M.Jourdan, M.Zimmermann, L.Skrisovska, C.Maris, L.Peng, C.Hofr, R.B.Emeson, F.H.Allain.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

23001123

G.I.Rice, P.R.Kasher, G.M.Forte, N.M.Mannion, S.M.Greenwood, M.Szynkiewicz, J.E.Dickerson, S.S.Bhaskar, M.Zampini, T.A.Briggs, E.M.Jenkinson, C.A.Bacino, R.Battini, E.Bertini, P.A.Brogan, L.A.Brueton, M.Carpanelli, C.De Laet, P.de Lonlay, M.Del Toro, I.Desguerre, E.Fazzi, A.Garcia-Cazorla, A.Heiberg, M.Kawaguchi, R.Kumar, J.P.Lin, C.M.Lourenco, A.M.Male, W.Marques, C.Mignot, I.Olivieri, S.Orcesi, P.Prabhakar, M.Rasmussen, R.A.Robinson, F.Rozenberg, J.L.Schmidt, K.Steindl, T.Y.Tan, W.G.van der Merwe, A.Vanderver, G.Vassallo, E.L.Wakeling, E.Wassmer, E.Whittaker, J.H.Livingston, P.Lebon, T.Suzuki, P.J.McLaughlin, L.P.Keegan, M.A.O'Connell, S.C.Lovell, and Y.J.Crow (2012).
Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature.

Nat Genet, 44, 1243-1248.

21145228

S.R.Nallagatla, R.Toroney, and P.C.Bevilacqua (2011).
Regulation of innate immunity through RNA structure and the protein kinase PKR.

Curr Opin Struct Biol, 21, 119-127.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.