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PDBsum entry 2ja2
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protein ligands metals links
Ligase PDB id
2ja2

 

 

 

 

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JSmol PyMol  
Contents
Protein chain
485 a.a. *
Ligands
ACT
Metals
_CL
Waters ×406
* Residue conservation analysis
PDB id:
2ja2
Name: Ligase
Title: Mycobacterium tuberculosis glutamyl-tRNA synthetase
Structure: Glutamyl-tRNA synthetase. Chain: a. Synonym: glutamate-tRNA ligase, glurs. Engineered: yes
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: p53b
Resolution:
1.65Å     R-factor:   0.208     R-free:   0.251
Authors: G.P.Bourenkov,N.Strizhov,L.A.Shkolnaya,M.Bruning,H.D.Bartunik
Key ref: G.P.Bourenkov et al. Structural basis for discriminating or non- Discriminating functioning of glutamyl-Trna synthetases. To be published, .
Date:
20-Nov-06     Release date:   28-Oct-08    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P9WFV9  (SYE_MYCTU) -  Glutamate--tRNA ligase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Seq:
Struc: 		490 a.a.
485 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.6.1.1.17  - glutamate--tRNA ligase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate
tRNA(Glu)
 +
L-glutamate
Bound ligand (Het Group name = ACT)
matches with 40.00% similarity 		+ ATP
 = L-glutamyl-tRNA(Glu)
 + AMP
 + diphosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

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