PDBsum entry 2iot

Hydrolase

PDB id: 2iot

Contents

Protein chain

240 a.a. *

Ligands

SO4

CL5

Waters ×347

* Residue conservation analysis

PDB id:

2iot

Name:

Hydrolase

Title:

Clavulanic acid bound to elastase

Structure:

Elastase-1. Chain: a. Ec: 3.4.21.36

Source:

Sus scrofa. Pig. Organism_taxid: 9823

Resolution:

1.60Å R-factor: 0.208 R-free: 0.235

Authors:

C.Farady,M.A.Navia

Key ref:

C.Farady et al. Elastase inhibition by clavulanic acid, And inhibitor of bacterial b-Lactamases: mechanistic and structural studies. To be published, .

Date:

10-Oct-06 Release date: 08-Apr-08

Protein chain

P00772  (CELA1_PIG) -  Chymotrypsin-like elastase family member 1 from Sus scrofa

Seq: 266 a.a.

Struc: 240 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.21.36 - pancreatic elastase.
• Reaction: Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa.