spacer
spacer

PDBsum entry 2hyd
Go to PDB code: 
protein ligands metals Protein-protein interface(s) links
Transport protein PDB id
2hyd

 

 

 

 

Loading ...

 
JSmol PyMol  
Contents
Protein chains
578 a.a. *
Ligands
ADP ×2
Metals
_NA ×2
Waters ×16
* Residue conservation analysis
PDB id:
2hyd
Name: Transport protein
Title: Multidrug abc transporter sav1866
Structure: Abc transporter homolog. Chain: a, b. Engineered: yes
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: sav1866. Expressed in: escherichia coli. Expression_system_taxid: 562
Biol. unit: Dimer (from PQS)
Resolution:
3.00Å     R-factor:   0.255     R-free:   0.272
Authors: R.J.P.Dawson,K.P.Locher
Key ref:
R.J.Dawson and K.P.Locher (2006). Structure of a bacterial multidrug ABC transporter. Nature, 443, 180-185. PubMed id: 16943773 DOI: 10.1038/nature05155
Date:
05-Aug-06     Release date:   05-Sep-06    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q99T13  (Y1866_STAAM) -  Putative multidrug export ATP-binding/permease protein SAV1866 from Staphylococcus aureus (strain Mu50 / ATCC 700699)
Seq:
Struc: 		 
Seq:
Struc: 		578 a.a.
578 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.7.6.2.-  - ?????
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

 

 
DOI no: 10.1038/nature05155 Nature 443:180-185 (2006)
PubMed id: 16943773  
 
 
Structure of a bacterial multidrug ABC transporter.
R.J.Dawson, K.P.Locher.
 
  ABSTRACT  
 
Multidrug transporters of the ABC family facilitate the export of diverse cytotoxic drugs across cell membranes. This is clinically relevant, as tumour cells may become resistant to agents used in chemotherapy. To understand the molecular basis of this process, we have determined the 3.0 A crystal structure of a bacterial ABC transporter (Sav1866) from Staphylococcus aureus. The homodimeric protein consists of 12 transmembrane helices in an arrangement that is consistent with cross-linking studies and electron microscopic imaging of the human multidrug resistance protein MDR1, but critically different from that reported for the bacterial lipid flippase MsbA. The observed, outward-facing conformation reflects the ATP-bound state, with the two nucleotide-binding domains in close contact and the two transmembrane domains forming a central cavity--presumably the drug translocation pathway--that is shielded from the inner leaflet of the lipid bilayer and from the cytoplasm, but exposed to the outer leaflet and the extracellular space.
 
  Selected figure(s)  
 
Figure 3.
Figure 3: Transmission interface.
Figure 3 : Transmission interface. Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com-
a, Close-up view of Sav1866 with one subunit in turquoise ribbon representation, the other in yellow coil representation. For clarity, only the ICL regions of the transmembrane domains are shown. Black spheres depict the first and last C positions of the 'coupling helices' (see the text). Side chains of the conserved Glu 473 and Tyr 391 are in ball-and-stick representation. b, Alignment of the Sav1866 protein sequence with those of other ABC transporters. Residues with high conservation are shaded dark grey, those with significant conservation are shaded light grey, and relevant motifs are shaded blue and indicated. Residues of the ICLs interacting (4 Å cut-off) with the NBD of the same subunit are indicated with green shading, and those contacting the opposite NBD with yellow shading. Residues of the NBD interacting with the TMD are shown with red shading. 		Figure 5.
Figure 5: ABC exporter schematics.
Figure 5 : ABC exporter schematics. Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com-
a, Earlier cartoons depict two compact transporter halves (subunits) arranged side-by-side, suggesting separation during the transport cycle. The grey box indicates the location of the membrane. b, Schematic of Sav1866 in the observed, outward-facing conformation. The cartoon emphasizes the domain swapping and subunit twisting. Arrows indicate the release of bound drug into the extracellular space.
 
  The above figures are reprinted by permission from Macmillan Publishers Ltd: Nature (2006, 443, 180-185) copyright 2006.  
  Figures were selected by an automated process.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
23142986 J.S.Woo, A.Zeltina, B.A.Goetz, and K.P.Locher (2012).
X-ray structure of the Yersinia pestis heme transporter HmuUV.
  Nat Struct Mol Biol, 19, 1310-1315.
PDB code: 4g1u
22447242 M.Hohl, C.Briand, M.G.Grütter, and M.A.Seeger (2012).
Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation.
  Nat Struct Mol Biol, 19, 395-402.
PDB code: 3qf4
23000901 V.M.Korkhov, S.A.Mireku, and K.P.Locher (2012).
Structure of AMP-PNP-bound vitamin B12 transporter BtuCD-F.
  Nature, 490, 367-372.
PDB code: 4fi3
21419343 A.Khushoo, Z.Yang, A.E.Johnson, and W.R.Skach (2011).
Ligand-driven vectorial folding of ribosome-bound human CFTR NBD1.
  Mol Cell, 41, 682-692.  
  21488101 A.S.Oliveira, A.M.Baptista, and C.M.Soares (2011).
Conformational changes induced by ATP-hydrolysis in an ABC transporter: A molecular dynamics study of the Sav1866 exporter.
  Proteins, 79, 1977-1990.  
21504024 B.Seantier, M.Dezi, F.Gubellini, A.Berquand, C.Godefroy, P.Dosset, D.Lévy, and P.E.Milhiet (2011).
Transfer on hydrophobic substrates and AFM imaging of membrane proteins reconstituted in planar lipid bilayers.
  J Mol Recognit, 24, 461-466.  
21275046 E.Noy, and H.Senderowitz (2011).
Combating Cystic Fibrosis: In Search for CF Transmembrane Conductance Regulator (CFTR) Modulators.
  ChemMedChem, 6, 243-251.  
21706007 G.B.Erkens, R.P.Berntsson, F.Fulyani, M.Majsnerowska, A.VujiÄić-Žagar, J.Ter Beek, B.Poolman, and D.J.Slotboom (2011).
The structural basis of modularity in ECF-type ABC transporters.
  Nat Struct Mol Biol, 18, 755-760.
PDB code: 3rlb
21441914 G.J.Williams, R.S.Williams, J.S.Williams, G.Moncalian, A.S.Arvai, O.Limbo, G.Guenther, S.Sildas, M.Hammel, P.Russell, and J.A.Tainer (2011).
ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.
  Nat Struct Mol Biol, 18, 423-431.
PDB codes: 3qkr 3qks 3qkt 3qku
21194365 R.P.Gupta, P.Kueppers, L.Schmitt, and R.Ernst (2011).
The multidrug transporter Pdr5: a molecular diode?
  Biol Chem, 392, 53-60.  
20439763 C.Baldauf, S.Schrodt, M.Herget, J.Koch, and R.Tampé (2010).
Single residue within the antigen translocation complex TAP controls the epitope repertoire by stabilizing a receptive conformation.
  Proc Natl Acad Sci U S A, 107, 9135-9140.  
21059948 C.Orelle, F.J.Alvarez, M.L.Oldham, A.Orelle, T.E.Wiley, J.Chen, and A.L.Davidson (2010).
Dynamics of alpha-helical subdomain rotation in the intact maltose ATP-binding cassette transporter.
  Proc Natl Acad Sci U S A, 107, 20293-20298.  
19819701 D.A.Gutmann, A.Ward, I.L.Urbatsch, G.Chang, and H.W.van Veen (2010).
Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1.
  Trends Biochem Sci, 35, 36-42.  
20644544 D.Parcej, and R.Tampé (2010).
ABC proteins in antigen translocation and viral inhibition.
  Nat Chem Biol, 6, 572-580.  
20731718 E.Crowley, M.L.O'Mara, I.D.Kerr, and R.Callaghan (2010).
Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1.
  FEBS J, 277, 3974-3985.  
19857594 E.Lamping, P.V.Baret, A.R.Holmes, B.C.Monk, A.Goffeau, and R.D.Cannon (2010).
Fungal PDR transporters: Phylogeny, topology, motifs and function.
  Fungal Genet Biol, 47, 127-142.  
20658906 F.Becq, and A.Billet (2010).
Understanding nucleotide binding and CFTR ion channel gating: how many cycles?
  Expert Rev Respir Med, 4, 451-454.  
21152102 H.Hoelen, B.Kleizen, A.Schmidt, J.Richardson, P.Charitou, P.J.Thomas, and I.Braakman (2010).
The primary folding defect and rescue of ΔF508 CFTR emerge during translation of the mutant domain.
  PLoS One, 5, e15458.  
19961540 I.D.Kerr, P.M.Jones, and A.M.George (2010).
Multidrug efflux pumps: the structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues.
  FEBS J, 277, 550-563.  
20454684 J.Aittoniemi, H.de Wet, F.M.Ashcroft, and M.S.Sansom (2010).
Asymmetric switching in a homodimeric ABC transporter: a simulation study.
  PLoS Comput Biol, 6, e1000762.  
20652498 J.S.Ham, S.G.Lee, S.G.Jeong, M.H.Oh, D.H.Kim, T.Lee, B.Y.Lee, S.H.Yoon, and H.Kim (2010).
Powerful usage of phylogenetically diverse Staphylococcus aureus control strains for detecting multidrug resistance genes in transcriptomics studies.
  Mol Cells, 30, 71-76.  
20809990 J.V.Møller, C.Olesen, A.M.Winther, and P.Nissen (2010).
The sarcoplasmic Ca2+-ATPase: design of a perfect chemi-osmotic pump.
  Q Rev Biophys, 43, 501-566.  
19996093 J.W.Weng, K.N.Fan, and W.N.Wang (2010).
The conformational transition pathway of ATP binding cassette transporter MsbA revealed by atomistic simulations.
  J Biol Chem, 285, 3053-3063.  
19826804 K.McLuskey, A.W.Roszak, Y.Zhu, and N.W.Isaacs (2010).
Crystal structures of all-alpha type membrane proteins.
  Eur Biophys J, 39, 723-755.  
20667175 K.R.Vinothkumar, and R.Henderson (2010).
Structures of membrane proteins.
  Q Rev Biophys, 43, 65.  
20179345 K.Terakado, A.Kodan, H.Nakano, Y.Kimura, K.Ueda, T.Nakatsu, and H.Kato (2010).
Deleting two C-terminal alpha-helices is effective to crystallize the bacterial ABC transporter Escherichia coli MsbA complexed with AMP-PNP.
  Acta Crystallogr D Biol Crystallogr, 66, 319-323.  
20123128 K.W.Hung, Y.W.Chang, E.T.Eng, J.H.Chen, Y.C.Chen, Y.J.Sun, C.D.Hsiao, G.Dong, K.A.Spasov, V.M.Unger, and T.H.Huang (2010).
Structural fold, conservation and Fe(II) binding of the intracellular domain of prokaryote FeoB.
  J Struct Biol, 170, 501-512.
PDB codes: 2wia 2wib 2wic 3k53
20799350 L.Kelly, H.Fukushima, R.Karchin, J.M.Gow, L.W.Chinn, U.Pieper, M.R.Segal, D.L.Kroetz, and A.Sali (2010).
Functional hot spots in human ATP-binding cassette transporter nucleotide binding domains.
  Protein Sci, 19, 2110-2121.  
20399185 M.F.Rosenberg, Z.Bikadi, J.Chan, X.Liu, Z.Ni, X.Cai, R.C.Ford, and Q.Mao (2010).
The human breast cancer resistance protein (BCRP/ABCG2) shows conformational changes with mitoxantrone.
  Structure, 18, 482-493.  
19947657 N.A.Impellitteri, J.A.Merten, L.E.Bretscher, and C.S.Klug (2010).
Identification of a functionally important loop in Salmonella typhimurium ArnT.
  Biochemistry, 49, 29-35.  
20976528 O.Kalid, M.Mense, S.Fischman, A.Shitrit, H.Bihler, E.Ben-Zeev, N.Schutz, N.Pedemonte, P.J.Thomas, R.J.Bridges, D.R.Wetmore, Y.Marantz, and H.Senderowitz (2010).
Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening.
  J Comput Aided Mol Des, 24, 971-991.  
20088606 O.Polgar, C.Ierano, A.Tamaki, B.Stanley, Y.Ward, D.Xia, N.Tarasova, R.W.Robey, and S.E.Bates (2010).
Mutational analysis of threonine 402 adjacent to the GXXXG dimerization motif in transmembrane segment 1 of ABCG2.
  Biochemistry, 49, 2235-2245.  
20715055 R.Doshi, B.Woebking, and H.W.van Veen (2010).
Dissection of the conformational cycle of the multidrug/lipidA ABC exporter MsbA.
  Proteins, 78, 2867-2872.  
19961541 R.Ernst, P.Kueppers, J.Stindt, K.Kuchler, and L.Schmitt (2010).
Multidrug efflux pumps: substrate selection in ATP-binding cassette multidrug efflux pumps--first come, first served?
  FEBS J, 277, 540-549.  
20150177 S.Atwell, C.G.Brouillette, K.Conners, S.Emtage, T.Gheyi, W.B.Guggino, J.Hendle, J.F.Hunt, H.A.Lewis, F.Lu, I.I.Protasevich, L.A.Rodgers, R.Romero, S.R.Wasserman, P.C.Weber, D.Wetmore, F.F.Zhang, and X.Zhao (2010).
Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
  Protein Eng Des Sel, 23, 375-384.
PDB codes: 2pze 2pzf 2pzg
20138191 T.Ishikawa, A.Sakurai, H.Hirano, A.Lezhava, M.Sakurai, and Y.Hayashizaki (2010).
Emerging new technologies in Pharmacogenomics: rapid SNP detection, molecular dynamic simulation, and QSAR analysis methods to validate clinically important genetic variants of human ABC Transporter ABCB1 (P-gp/MDR1).
  Pharmacol Ther, 126, 69-81.  
19927121 V.Kanelis, R.P.Hudson, P.H.Thibodeau, P.J.Thomas, and J.D.Forman-Kay (2010).
NMR evidence for differential phosphorylation-dependent interactions in WT and DeltaF508 CFTR.
  EMBO J, 29, 263-277.  
20541505 V.M.Korkhov, C.Sachse, J.M.Short, and C.G.Tate (2010).
Three-dimensional structure of TspO by electron cryomicroscopy of helical crystals.
  Structure, 18, 677-687.  
20133716 W.Wang, J.Wu, K.Bernard, G.Li, G.Wang, M.O.Bevensee, and K.L.Kirk (2010).
ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.
  Proc Natl Acad Sci U S A, 107, 3888-3893.  
  20805575 Y.Bai, M.Li, and T.C.Hwang (2010).
Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation.
  J Gen Physiol, 136, 293-309.  
20412585 Z.He, and J.De Buck (2010).
Cell wall proteome analysis of Mycobacterium smegmatis strain MC2 155.
  BMC Microbiol, 10, 121.  
  21078867 Z.Kopeikin, Y.Sohma, M.Li, and T.C.Hwang (2010).
On the mechanism of CFTR inhibition by a thiazolidinone derivative.
  J Gen Physiol, 136, 659-671.  
20812902 Z.Ni, Z.Bikadi, M.F.Rosenberg, and Q.Mao (2010).
Structure and function of the human breast cancer resistance protein (BCRP/ABCG2).
  Curr Drug Metab, 11, 603-617.  
19383151 A.Sturm, P.Cunningham, and M.Dean (2009).
The ABC transporter gene family of Daphnia pulex.
  BMC Genomics, 10, 170.  
  19732422 A.W.Ravna, I.Sylte, and G.Sager (2009).
Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure.
  Theor Biol Med Model, 6, 20.  
19114108 A.Ward, S.Mulligan, B.Carragher, G.Chang, and R.A.Milligan (2009).
Nucleotide dependent packing differences in helical crystals of the ABC transporter MsbA.
  J Struct Biol, 165, 169-175.  
19124053 C.A.McDevitt, R.Collins, I.D.Kerr, and R.Callaghan (2009).
Purification and structural analyses of ABCG2.
  Adv Drug Deliv Rev, 61, 57-65.  
19754156 C.Alexander, A.Ivetac, X.Liu, Y.Norimatsu, J.R.Serrano, A.Landstrom, M.Sansom, and D.C.Dawson (2009).
Cystic fibrosis transmembrane conductance regulator: using differential reactivity toward channel-permeant and channel-impermeant thiol-reactive probes to test a molecular model for the pore.
  Biochemistry, 48, 10078-10088.  
19946134 C.M.Paumi, M.Chuk, J.Snider, I.Stagljar, and S.Michaelis (2009).
ABC transporters in Saccharomyces cerevisiae and their interactors: new technology advances the biology of the ABCC (MRP) subfamily.
  Microbiol Mol Biol Rev, 73, 577-593.  
19426129 C.Schölz, and R.Tampé (2009).
The peptide-loading complex--antigen translocation and MHC class I loading.
  Biol Chem, 390, 783-794.  
19339978 D.C.Gadsby (2009).
Ion channels versus ion pumps: the principal difference, in principle.
  Nat Rev Mol Cell Biol, 10, 344-352.  
19234479 D.C.Rees, E.Johnson, and O.Lewinson (2009).
ABC transporters: the power to change.
  Nat Rev Mol Cell Biol, 10, 218-227.  
19019987 D.Dietrich, H.Schmuths, C.d.e. .M.Lousa, J.M.Baldwin, S.A.Baldwin, A.Baker, F.L.Theodoulou, and M.J.Holdsworth (2009).
Mutations in the Arabidopsis peroxisomal ABC transporter COMATOSE allow differentiation between multiple functions in planta: insights from an allelic series.
  Mol Biol Cell, 20, 530-543.  
19625452 D.E.Grove, M.F.Rosser, H.Y.Ren, A.P.Naren, and D.M.Cyr (2009).
Mechanisms for rescue of correctable folding defects in CFTRDelta F508.
  Mol Biol Cell, 20, 4059-4069.  
19177345 D.E.Tronrud, and B.W.Matthews (2009).
Sorting the chaff from the wheat at the PDB.
  Protein Sci, 18, 2-5.  
18957373 D.Muallem, and P.Vergani (2009).
Review. ATP hydrolysis-driven gating in cystic fibrosis transmembrane conductance regulator.
  Philos Trans R Soc Lond B Biol Sci, 364, 247-255.  
19053133 D.Parcej, and R.Tampé (2009).
Solute-binding sites in ABC transporters for recognition, occlusion and trans-inhibition.
  ChemMedChem, 4, 25-28.  
19456124 E.Crowley, M.L.O'Mara, C.Reynolds, D.P.Tieleman, J.Storm, I.D.Kerr, and R.Callaghan (2009).
Transmembrane helix 12 modulates progression of the ATP catalytic cycle in ABCB1.
  Biochemistry, 48, 6249-6258.  
19135106 E.Nicolle, A.Boumendjel, S.Macalou, E.Genoux, A.Ahmed-Belkacem, P.A.Carrupt, and A.Di Pietro (2009).
QSAR analysis and molecular modeling of ABCG2-specific inhibitors.
  Adv Drug Deliv Rev, 61, 34-46.  
19261456 E.Procko, and R.Gaudet (2009).
Antigen processing and presentation: TAPping into ABC transporters.
  Curr Opin Immunol, 21, 84-91.  
19418088 G.K.Wang, J.Calderon, S.J.Jaw, and S.Y.Wang (2009).
State-dependent block of Na+ channels by articaine via the local anesthetic receptor.
  J Membr Biol, 229, 1-9.  
19297616 G.Oancea, M.L.O'Mara, W.F.Bennett, D.P.Tieleman, R.Abele, and R.Tampé (2009).
Structural arrangement of the transmission interface in the antigen ABC transport complex TAP.
  Proc Natl Acad Sci U S A, 106, 5551-5556.  
19722844 H.I.Zgurskaya (2009).
Multicomponent drug efflux complexes: architecture and mechanism of assembly.
  Future Microbiol, 4, 919-932.  
19697963 H.Li, and D.N.Sheppard (2009).
Therapeutic potential of cystic fibrosis transmembrane conductance regulator (CFTR) inhibitors in polycystic kidney disease.
  BioDrugs, 23, 203-216.  
19231985 H.Nikaido (2009).
Multidrug resistance in bacteria.
  Annu Rev Biochem, 78, 119-146.  
19309458 H.Yang, and A.S.Murphy (2009).
Functional expression and characterization of Arabidopsis ABCB, AUX 1 and PIN auxin transporters in Schizosaccharomyces pombe.
  Plant J, 59, 179-191.  
18990670 J.Aittoniemi, C.Fotinou, T.J.Craig, H.de Wet, P.Proks, and F.M.Ashcroft (2009).
Review. SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator.
  Philos Trans R Soc Lond B Biol Sci, 364, 257-267.  
19207745 J.L.Martinez, M.B.Sánchez, L.Martínez-Solano, A.Hernandez, L.Garmendia, A.Fajardo, and C.Alvarez-Ortega (2009).
Functional role of bacterial multidrug efflux pumps in microbial natural ecosystems.
  FEMS Microbiol Rev, 33, 430-449.  
19159494 J.P.Becker, G.Depret, F.Van Bambeke, P.M.Tulkens, and M.Prévost (2009).
Molecular models of human P-glycoprotein in two different catalytic states.
  BMC Struct Biol, 9, 3.  
19594831 J.Prosecka, A.V.Orlov, Y.S.Fantin, V.V.Zinchenko, M.M.Babykin, and M.Tichy (2009).
A novel ATP-binding cassette transporter is responsible for resistance to viologen herbicides in the cyanobacterium Synechocystis sp. PCC 6803.
  FEBS J, 276, 4001-4011.  
19288491 K.F.Chan, Y.Zhao, T.W.Chow, C.S.Yan, D.L.Ma, B.A.Burkett, I.L.Wong, L.M.Chow, and T.H.Chan (2009).
Flavonoid dimers as bivalent modulators for p-glycoprotein-based multidrug resistance: structure-activity relationships.
  ChemMedChem, 4, 594-614.  
18957379 K.P.Locher (2009).
Review. Structure and mechanism of ATP-binding cassette transporters.
  Philos Trans R Soc Lond B Biol Sci, 364, 239-245.  
19760129 L.Kelly, U.Pieper, N.Eswar, F.A.Hays, M.Li, Z.Roe-Zurz, D.L.Kroetz, K.M.Giacomini, R.M.Stroud, and A.Sali (2009).
A survey of integral alpha-helical membrane proteins.
  J Struct Funct Genomics, 10, 269-280.  
19495992 L.Xing, Y.Hu, and Y.Lai (2009).
Advancement of structure-activity relationship of multidrug resistance-associated protein 2 interactions.
  AAPS J, 11, 406-413.  
19937827 M.A.Demel, O.Krämer, P.Ettmayer, E.E.Haaksma, and G.F.Ecker (2009).
Predicting ligand interactions with ABC transporters in ADME.
  Chem Biodivers, 6, 1960-1969.  
19479721 M.A.Do Cao, S.Crouzy, M.Kim, M.Becchi, D.S.Cafiso, A.Di Pietro, and J.M.Jault (2009).
Probing the conformation of the resting state of a bacterial multidrug ABC transporter, BmrA, by a site-directed spin labeling approach.
  Protein Sci, 18, 1507-1520.  
19381710 M.Fatehi, and P.Linsdell (2009).
Novel residues lining the CFTR chloride channel pore identified by functional modification of introduced cysteines.
  J Membr Biol, 228, 151-164.  
19808685 M.Herget, N.Kreissig, C.Kolbe, C.Schölz, R.Tampé, and R.Abele (2009).
Purification and reconstitution of the antigen transport complex TAP: a prerequisite for determination of peptide stoichiometry and ATP hydrolysis.
  J Biol Chem, 284, 33740-33749.  
19258317 M.Hozoji, Y.Kimura, N.Kioka, and K.Ueda (2009).
Formation of Two Intramolecular Disulfide Bonds Is Necessary for ApoA-I-dependent Cholesterol Efflux Mediated by ABCA1.
  J Biol Chem, 284, 11293-11300.  
  20142853 M.Jose, and S.V.Thomas (2009).
Role of multidrug transporters in neurotherapeutics.
  Ann Indian Acad Neurol, 12, 89-98.  
19513059 M.M.Gottesman, S.V.Ambudkar, and D.Xia (2009).
Structure of a multidrug transporter.
  Nat Biotechnol, 27, 546-547.  
19393219 N.Puri, M.Gaur, M.Sharma, S.Shukla, S.V.Ambudkar, and R.Prasad (2009).
The amino acid residues of transmembrane helix 5 of multidrug resistance protein CaCdr1p of Candida albicans are involved in substrate specificity and drug transport.
  Biochim Biophys Acta, 1788, 1752-1761.  
19171975 P.D.Jeffrey (2009).
Analysis of errors in the structure determination of MsbA.
  Acta Crystallogr D Biol Crystallogr, 65, 193-199.  
18831048 P.M.Jones, and A.M.George (2009).
Opening of the ADP-bound active site in the ABC transporter ATPase dimer: evidence for a constant contact, alternating sites model for the catalytic cycle.
  Proteins, 75, 387-396.  
19748784 P.M.Jones, M.L.O'Mara, and A.M.George (2009).
ABC transporters: a riddle wrapped in a mystery inside an enigma.
  Trends Biochem Sci, 34, 520-531.  
19416657 P.T.Tarr, E.J.Tarling, D.D.Bojanic, P.A.Edwards, and A.Baldán (2009).
Emerging new paradigms for ABCG transporters.
  Biochim Biophys Acta, 1791, 584-593.  
19715704 P.Zou, and H.S.McHaourab (2009).
Alternating access of the putative substrate-binding chamber in the ABC transporter MsbA.
  J Mol Biol, 393, 574-585.  
19715702 P.Zou, M.Bortolus, and H.S.McHaourab (2009).
Conformational cycle of the ABC transporter MsbA in liposomes: detailed analysis using double electron-electron resonance spectroscopy.
  J Mol Biol, 393, 586-597.  
19054062 Q.Li, Q.Jiang, E.Pfendner, A.Váradi, and J.Uitto (2009).
Pseudoxanthoma elasticum: clinical phenotypes, molecular genetics and putative pathomechanisms.
  Exp Dermatol, 18, 1.  
19366916 R.D.Cannon, E.Lamping, A.R.Holmes, K.Niimi, P.V.Baret, M.V.Keniya, K.Tanabe, M.Niimi, A.Goffeau, and B.C.Monk (2009).
Efflux-mediated antifungal drug resistance.
  Clin Microbiol Rev, 22, 291.  
19265398 S.Balaz (2009).
Modeling kinetics of subcellular disposition of chemicals.
  Chem Rev, 109, 1793-1899.  
19325113 S.G.Aller, J.Yu, A.Ward, Y.Weng, S.Chittaboina, R.Zhuo, P.M.Harrell, Y.T.Trinh, Q.Zhang, I.L.Urbatsch, and G.Chang (2009).
Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.
  Science, 323, 1718-1722.
PDB codes: 3g5u 3g60 3g61
19593434 S.Velamakanni, C.H.Lau, D.A.Gutmann, H.Venter, N.P.Barrera, M.A.Seeger, B.Woebking, D.Matak-Vinkovic, L.Balakrishnan, Y.Yao, E.C.U, R.A.Shilling, C.V.Robinson, P.Thorn, and H.W.van Veen (2009).
A multidrug ABC transporter with a taste for salt.
  PLoS One, 4, e6137.  
19167254 S.Y.Huang, D.Bolser, H.Y.Liu, T.C.Hwang, and X.Zou (2009).
Molecular modeling of the heterodimer of human CFTR's nucleotide-binding domains using a protein-protein docking approach.
  J Mol Graph Model, 27, 822-828.  
19278995 Smriti, P.Zou, and H.S.McHaourab (2009).
Mapping Daunorubicin-binding Sites in the ATP-binding Cassette Transporter MsbA Using Site-specific Quenching by Spin Labels.
  J Biol Chem, 284, 13904-13913.  
19581304 T.W.Loo, M.C.Bartlett, and D.M.Clarke (2009).
Identification of residues in the drug translocation pathway of the human multidrug resistance P-glycoprotein by arginine mutagenesis.
  J Biol Chem, 284, 24074-24087.  
19642168 V.Keitel, M.Burdelski, Z.Vojnisek, L.Schmitt, D.Häussinger, and R.Kubitz (2009).
De novo bile salt transporter antibodies as a possible cause of recurrent graft failure after liver transplantation: a novel mechanism of cholestasis.
  Hepatology, 50, 510-517.  
19544044 V.Kos, and R.C.Ford (2009).
The ATP-binding cassette family: a structural perspective.
  Cell Mol Life Sci, 66, 3111-3126.  
19678712 X.Z.Li, and H.Nikaido (2009).
Efflux-mediated drug resistance in bacteria: an update.
  Drugs, 69, 1555-1623.  
19781551 Y.Zhou, Y.Nie, and H.R.Kaback (2009).
Residues gating the periplasmic pathway of LacY.
  J Mol Biol, 394, 219-225.  
18160405 A.Karcher, A.Schele, and K.P.Hopfner (2008).
X-ray structure of the complete ABC enzyme ABCE1 from Pyrococcus abyssi.
  J Biol Chem, 283, 7962-7971.
PDB code: 3bk7
18535149 A.L.Davidson, E.Dassa, C.Orelle, and J.Chen (2008).
Structure, function, and evolution of bacterial ATP-binding cassette systems.
  Microbiol Mol Biol Rev, 72, 317.  
18281290 A.P.Babenko (2008).
A novel ABCC8 (SUR1)-dependent mechanism of metabolism-excitation uncoupling.
  J Biol Chem, 283, 8778-8782.  
17729275 A.Rath, and C.M.Deber (2008).
Surface recognition elements of membrane protein oligomerization.
  Proteins, 70, 786-793.  
  18540059 A.S.Ethayathulla, Y.Bessho, A.Shinkai, B.Padmanabhan, T.P.Singh, P.Kaur, and S.Yokoyama (2008).
Purification, crystallization and preliminary X-ray diffraction analysis of the putative ABC transporter ATP-binding protein from Thermotoga maritima.
  Acta Crystallogr Sect F Struct Biol Cryst Commun, 64, 498-500.  
18305154 A.W.Serohijos, T.Hegedus, A.A.Aleksandrov, L.He, L.Cui, N.V.Dokholyan, and J.R.Riordan (2008).
Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function.
  Proc Natl Acad Sci U S A, 105, 3256-3261.  
18463704 A.W.Serohijos, T.Hegedus, J.R.Riordan, and N.V.Dokholyan (2008).
Diminished self-chaperoning activity of the DeltaF508 mutant of CFTR results in protein misfolding.
  PLoS Comput Biol, 4, e1000008.  
18175303 C.Globisch, I.K.Pajeva, and M.Wiese (2008).
Identification of putative binding sites of P-glycoprotein based on its homology model.
  ChemMedChem, 3, 280-295.  
18722384 C.J.Tsai, Z.E.Sauna, C.Kimchi-Sarfaty, S.V.Ambudkar, M.M.Gottesman, and R.Nussinov (2008).
Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima.
  J Mol Biol, 383, 281-291.  
  19079736 C.P.Wu, A.M.Calcagno, and S.V.Ambudkar (2008).
Reversal of ABC drug transporter-mediated multidrug resistance in cancer cells: evaluation of current strategies.
  Curr Mol Pharmacol, 1, 93.  
18781607 D.Gotthardt, H.Runz, V.Keitel, C.Fischer, C.Flechtenmacher, M.Wirtenberger, K.H.Weiss, S.Imparato, A.Braun, K.Hemminki, W.Stremmel, F.Rüschendorf, A.Stiehl, R.Kubitz, B.Burwinkel, P.Schirmacher, A.S.Knisely, J.Zschocke, and P.Sauer (2008).
A mutation in the canalicular phospholipid transporter gene, ABCB4, is associated with cholestasis, ductopenia, and cirrhosis in adults.
  Hepatology, 48, 1157-1166.  
18056267 E.J.Beck, Y.Yang, S.Yaemsiri, and V.Raghuram (2008).
Conformational changes in a pore-lining helix coupled to cystic fibrosis transmembrane conductance regulator channel gating.
  J Biol Chem, 283, 4957-4966.  
18154452 F.J.Sharom (2008).
ABC multidrug transporters: structure, function and role in chemoresistance.
  Pharmacogenomics, 9, 105-127.  
18504552 F.Rafii, and M.Park (2008).
Detection and characterization of an ABC transporter in Clostridium hathewayi.
  Arch Microbiol, 190, 417-426.  
18405843 G.F.Ecker, T.Stockner, and P.Chiba (2008).
Computational models for prediction of interactions with ABC-transporters.
  Drug Discov Today, 13, 311-317.  
18468555 G.Szakács, A.Váradi, C.Ozvegy-Laczka, and B.Sarkadi (2008).
The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox).
  Drug Discov Today, 13, 379-393.  
18497752 H.de Wet, P.Proks, M.Lafond, J.Aittoniemi, M.S.Sansom, S.E.Flanagan, E.R.Pearson, A.T.Hattersley, and F.M.Ashcroft (2008).
A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes.
  EMBO Rep, 9, 648-654.  
18489584 I.Carrier, and P.Gros (2008).
Investigating the role of the invariant carboxylate residues E552 and E1197 in the catalytic activity of Abcb1a (mouse Mdr3).
  FEBS J, 275, 3312-3324.  
18042544 I.Lehner, D.Basting, B.Meyer, W.Haase, T.Manolikas, C.Kaiser, M.Karas, and C.Glaubitz (2008).
The Key Residue for Substrate Transport (Glu14) in the EmrE Dimer Is Asymmetric.
  J Biol Chem, 283, 3281-3288.  
18567672 I.N.Smirnova, V.Kasho, and H.R.Kaback (2008).
Protonation and sugar binding to LacY.
  Proc Natl Acad Sci U S A, 105, 8896-8901.  
18006157 J.K.Lekostaj, L.E.Amoah, and P.D.Roepe (2008).
A single S1034C mutation confers altered drug sensitivity to PfMDR1 ATPase activity that is characteristic of the 7G8 isoform.
  Mol Biochem Parasitol, 157, 107-111.  
18304008 J.R.Riordan (2008).
CFTR function and prospects for therapy.
  Annu Rev Biochem, 77, 701-726.  
18284576 J.S.Griffitts, and S.R.Long (2008).
A symbiotic mutant of Sinorhizobium meliloti reveals a novel genetic pathway involving succinoglycan biosynthetic functions.
  Mol Microbiol, 67, 1292-1306.  
17951296 J.Weng, J.Ma, K.Fan, and W.Wang (2008).
The conformational coupling and translocation mechanism of vitamin B12 ATP-binding cassette transporter BtuCD.
  Biophys J, 94, 612-621.  
18093977 J.Y.Lee, I.L.Urbatsch, A.E.Senior, and S.Wilkens (2008).
Nucleotide-induced structural changes in P-glycoprotein observed by electron microscopy.
  J Biol Chem, 283, 5769-5779.  
19053284 K.M.Westfahl, J.A.Merten, A.H.Buchaklian, and C.S.Klug (2008).
Functionally important ATP binding and hydrolysis sites in Escherichia coli MsbA.
  Biochemistry, 47, 13878-13886.  
17951378 K.Okuda, Y.Aso, J.Nakayama, and K.Sonomoto (2008).
Cooperative transport between NukFEG and NukH in immunity against the lantibiotic nukacin ISK-1 produced by Staphylococcus warneri ISK-1.
  J Bacteriol, 190, 356-362.  
18772896 L.Csanády, and J.A.Mindell (2008).
The twain shall meet: channels, transporters and things between. Meeting on Membrane Transport in Flux: the Ambiguous Interface Between Channels and Pumps.
  EMBO Rep, 9, 960-965.  
18658148 L.He, A.A.Aleksandrov, A.W.Serohijos, T.Hegedus, L.A.Aleksandrov, L.Cui, N.V.Dokholyan, and J.R.Riordan (2008).
Multiple membrane-cytoplasmic domain contacts in the cystic fibrosis transmembrane conductance regulator (CFTR) mediate regulation of channel gating.
  J Biol Chem, 283, 26383-26390.  
18721111 M.A.Demel, R.Schwaha, O.Krämer, P.Ettmayer, E.E.Haaksma, and G.F.Ecker (2008).
In silico prediction of substrate properties for ABC-multidrug transporters.
  Expert Opin Drug Metab Toxicol, 4, 1167-1180.  
18716059 M.F.Rosser, D.E.Grove, L.Chen, and D.M.Cyr (2008).
Assembly and misassembly of cystic fibrosis transmembrane conductance regulator: folding defects caused by deletion of F508 occur before and after the calnexin-dependent association of membrane spanning domain (MSD) 1 and MSD2.
  Mol Biol Cell, 19, 4570-4579.  
18567630 M.Grote, E.Bordignon, Y.Polyhach, G.Jeschke, H.J.Steinhoff, and E.Schneider (2008).
A comparative electron paramagnetic resonance study of the nucleotide-binding domains' catalytic cycle in the assembled maltose ATP-binding cassette importer.
  Biophys J, 95, 2924-2938.  
18948194 M.L.Oldham, A.L.Davidson, and J.Chen (2008).
Structural insights into ABC transporter mechanism.
  Curr Opin Struct Biol, 18, 726-733.  
18675588 M.Raghavan, N.Del Cid, S.M.Rizvi, and L.R.Peters (2008).
MHC class I assembly: out and about.
  Trends Immunol, 29, 436-443.  
18855017 M.Westerlund, A.C.Belin, L.Olson, and D.Galter (2008).
Expression of multi-drug resistance 1 mRNA in human and rodent tissues: reduced levels in Parkinson patients.
  Cell Tissue Res, 334, 179-185.  
18621668 N.S.Kadaba, J.T.Kaiser, E.Johnson, A.Lee, and D.C.Rees (2008).
The high-affinity E. coli methionine ABC transporter: structure and allosteric regulation.
  Science, 321, 250-253.
PDB codes: 3dhw 3dhx
18218629 N.Taniguchi, and H.Tokuda (2008).
Molecular events involved in a single cycle of ligand transfer from an ATP binding cassette transporter, LolCDE, to a molecular chaperone, LolA.
  J Biol Chem, 283, 8538-8544.  
18370855 O.Polgar, R.W.Robey, and S.E.Bates (2008).
ABCG2: structure, function and role in drug response.
  Expert Opin Drug Metab Toxicol, 4, 1.  
18230804 O.X.Cordero, B.Snel, and P.Hogeweg (2008).
Coevolution of gene families in prokaryotes.
  Genome Res, 18, 462-468.  
18344567 P.D.Eckford, and F.J.Sharom (2008).
Functional characterization of Escherichia coli MsbA: interaction with nucleotides and substrates.
  J Biol Chem, 283, 12840-12850.  
18356296 R.Ernst, P.Kueppers, C.M.Klein, T.Schwarzmueller, K.Kuchler, and L.Schmitt (2008).
A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5.
  Proc Natl Acad Sci U S A, 105, 5069-5074.  
18715873 R.Masia, and C.G.Nichols (2008).
Functional clustering of mutations in the dimer interface of the nucleotide binding folds of the sulfonylurea receptor.
  J Biol Chem, 283, 30322-30329.  
18088596 R.Yang, R.Scavetta, and X.B.Chang (2008).
The hydroxyl group of S685 in Walker A motif and the carboxyl group of D792 in Walker B motif of NBD1 play a crucial role for multidrug resistance protein folding and function.
  Biochim Biophys Acta, 1778, 454-465.  
18511655 S.Gerber, M.Comellas-Bigler, B.A.Goetz, and K.P.Locher (2008).
Structural basis of trans-inhibition in a molybdate/tungstate ABC transporter.
  Science, 321, 246-250.
PDB code: 3d31
18644782 S.Pagant, E.Y.Brovman, J.J.Halliday, and E.A.Miller (2008).
Mapping of interdomain interfaces required for the functional architecture of Yor1p, a eukaryotic ATP-binding cassette (ABC) transporter.
  J Biol Chem, 283, 26444-26451.  
18596043 T.W.Loo, M.C.Bartlett, and D.M.Clarke (2008).
Arginines in the First Transmembrane Segment Promote Maturation of a P-glycoprotein Processing Mutant by Hydrogen Bond Interactions with Tyrosines in Transmembrane Segment 11.
  J Biol Chem, 283, 24860-24870.  
18708637 T.W.Loo, M.C.Bartlett, and D.M.Clarke (2008).
Processing Mutations Disrupt Interactions between the Nucleotide Binding and Transmembrane Domains of P-glycoprotein and the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).
  J Biol Chem, 283, 28190-28197.  
18093093 U.Mamat, T.C.Meredith, P.Aggarwal, A.Kühl, P.Kirchhoff, B.Lindner, A.Hanuszkiewicz, J.Sun, O.Holst, and R.W.Woodard (2008).
Single amino acid substitutions in either YhjD or MsbA confer viability to 3-deoxy-d-manno-oct-2-ulosonic acid-depleted Escherichia coli.
  Mol Microbiol, 67, 633-648.  
18523872 U.Muenster, B.Grieshop, K.Ickenroth, and M.J.Gnoth (2008).
Characterization of substrates and inhibitors for the in vitro assessment of Bcrp mediated drug-drug interactions.
  Pharm Res, 25, 2320-2326.  
18295794 V.M.Korkhov, and C.G.Tate (2008).
Electron crystallography reveals plasticity within the drug binding site of the small multidrug transporter EmrE.
  J Mol Biol, 377, 1094-1103.  
18406332 V.N.Bavro, Z.Pietras, N.Furnham, L.Pérez-Cano, J.Fernández-Recio, X.Y.Pei, R.Misra, and B.Luisi (2008).
Assembly and channel opening in a bacterial drug efflux machine.
  Mol Cell, 30, 114-121.
PDB codes: 2vdd 2vde
18198173 Y.Shi, X.Chen, Z.Wu, W.Shi, Y.Yang, N.Cui, C.Jiang, and R.W.Harrison (2008).
cAMP-dependent protein kinase phosphorylation produces interdomain movement in SUR2B leading to activation of the vascular KATP channel.
  J Biol Chem, 283, 7523-7530.  
18319336 Y.Zhou, L.Guan, J.A.Freites, and H.R.Kaback (2008).
Opening and closing of the periplasmic gate in lactose permease.
  Proc Natl Acad Sci U S A, 105, 3774-3778.  
18842589 Z.E.Sauna, S.S.Bohn, R.Rutledge, M.P.Dougherty, S.Cronin, L.May, D.Xia, S.V.Ambudkar, and J.Golin (2008).
Mutations Define Cross-talk between the N-terminal Nucleotide-binding Domain and Transmembrane Helix-2 of the Yeast Multidrug Transporter Pdr5: POSSIBLE CONSERVATION OF A SIGNALING INTERFACE FOR COUPLING ATP HYDROLYSIS TO DRUG TRANSPORT.
  J Biol Chem, 283, 35010-35022.  
  17803828 A.W.Ravna, I.Sylte, and G.Sager (2007).
Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5).
  Theor Biol Med Model, 4, 33.  
18024585 A.Ward, C.L.Reyes, J.Yu, C.B.Roth, and G.Chang (2007).
Flexibility in the ABC transporter MsbA: Alternating access with a twist.
  Proc Natl Acad Sci U S A, 104, 19005-19010.
PDB codes: 3b5w 3b5x 3b5y 3b5z 3b60
17429392 C.F.Higgins (2007).
Multiple molecular mechanisms for multidrug resistance transporters.
  Nature, 446, 749-757.  
18075584 C.Olesen, M.Picard, A.M.Winther, C.Gyrup, J.P.Morth, C.Oxvig, J.V.Møller, and P.Nissen (2007).
The structural basis of calcium transport by the calcium pump.
  Nature, 450, 1036-1042.
PDB codes: 3b9b 3b9r 3ba6
17362200 C.R.Raetz, C.M.Reynolds, M.S.Trent, and R.E.Bishop (2007).
Lipid A modification systems in gram-negative bacteria.
  Annu Rev Biochem, 76, 295-329.  
17604270 C.Vedhachalam, P.T.Duong, M.Nickel, D.Nguyen, P.Dhanasekaran, H.Saito, G.H.Rothblat, S.Lund-Katz, and M.C.Phillips (2007).
Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles.
  J Biol Chem, 282, 25123-25130.  
17567744 D.A.Gutmann, E.Mizohata, S.Newstead, S.Ferrandon, V.Postis, X.Xia, P.J.Henderson, H.W.van Veen, and B.Byrne (2007).
A high-throughput method for membrane protein solubility screening: the ultracentrifugation dispersity sedimentation assay.
  Protein Sci, 16, 1422-1428.  
17726488 D.Degiorgio, C.Colombo, M.Seia, L.Porcaro, L.Costantino, L.Zazzeron, D.Bordo, and D.A.Coviello (2007).
Molecular characterization and structural implications of 25 new ABCB4 mutations in progressive familial intrahepatic cholestasis type 3 (PFIC3).
  Eur J Hum Genet, 15, 1230-1238.  
17972020 D.Nikles, and R.Tampé (2007).
Targeted degradation of ABC transporters in health and disease.
  J Bioenerg Biomembr, 39, 489-497.  
17444666 E.Kang, J.W.Park, S.J.McClellan, J.M.Kim, D.P.Holland, G.U.Lee, E.I.Franses, K.Park, and D.H.Thompson (2007).
Specific adsorption of histidine-tagged proteins on silica surfaces modified with Ni2+/NTA-derivatized poly(ethylene glycol).
  Langmuir, 23, 6281-6288.  
17547710 G.von Heijne (2007).
The membrane protein universe: what's out there and why bother?
  J Intern Med, 261, 543-557.  
17158291 H.W.Pinkett, A.T.Lee, P.Lum, K.P.Locher, and D.C.Rees (2007).
An inward-facing conformation of a putative metal-chelate-type ABC transporter.
  Science, 315, 373-377.
PDB code: 2nq2
17531815 J.J.Warren, T.J.Pohlhaus, A.Changela, R.R.Iyer, P.L.Modrich, and L.S.Beese (2007).
Structure of the human MutSalpha DNA lesion recognition complex.
  Mol Cell, 26, 579-592.
PDB codes: 2o8b 2o8c 2o8d 2o8e 2o8f
18080175 J.L.Mendoza, and P.J.Thomas (2007).
Building an understanding of cystic fibrosis on the foundation of ABC transporter structures.
  J Bioenerg Biomembr, 39, 499-505.  
17804667 J.Lubelski, W.N.Konings, and A.J.Driessen (2007).
Distribution and physiology of ABC-type transporters contributing to multidrug resistance in bacteria.
  Microbiol Mol Biol Rev, 71, 463-476.  
17660831 J.M.Baker, R.P.Hudson, V.Kanelis, W.Y.Choy, P.H.Thibodeau, P.J.Thomas, and J.D.Forman-Kay (2007).
CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices.
  Nat Struct Mol Biol, 14, 738-745.  
17208973 J.Sonne, C.Kandt, G.H.Peters, F.Y.Hansen, M.Ã.˜.Jensen, and D.P.Tieleman (2007).
Simulation of the coupling between nucleotide binding and transmembrane domains in the ATP binding cassette transporter BtuCD.
  Biophys J, 92, 2727-2734.  
  19461974 J.U.Flanagan, and T.Huber (2007).
Structural Evolution of the ABC Transporter Subfamily B.
  Evol Bioinform Online, 3, 309-316.  
17922514 J.Zheng, C.Wei, W.Leng, J.Dong, R.Li, W.Li, J.Wang, Z.Zhang, and Q.Jin (2007).
Membrane subproteomic analysis of Mycobacterium bovis bacillus Calmette-Guérin.
  Proteomics, 7, 3919-3931.  
17322901 K.Hollenstein, D.C.Frei, and K.P.Locher (2007).
Structure of an ABC transporter in complex with its binding protein.
  Nature, 446, 213-216.
PDB codes: 2onk 2onr 2ons
17881559 L.Guan, O.Mirza, G.Verner, S.Iwata, and H.R.Kaback (2007).
Structural determination of wild-type lactose permease.
  Proc Natl Acad Sci U S A, 104, 15294-15298.
PDB code: 2v8n
17164240 M.Herget, G.Oancea, S.Schrodt, M.Karas, R.Tampé, and R.Abele (2007).
Mechanism of substrate sensing and signal transmission within an ABC transporter: use of a Trojan horse strategy.
  J Biol Chem, 282, 3871-3880.  
17150958 M.Hofacker, S.Gompf, A.Zutz, C.Presenti, W.Haase, C.van der Does, K.Model, and R.Tampé (2007).
Structural and functional fingerprint of the mitochondrial ATP-binding cassette transporter Mdl1 from Saccharomyces cerevisiae.
  J Biol Chem, 282, 3951-3961.  
17545154 M.L.Daus, M.Grote, P.Müller, M.Doebber, A.Herrmann, H.J.Steinhoff, E.Dassa, and E.Schneider (2007).
ATP-driven MalK dimer closure and reopening and conformational changes of the "EAA" motifs are crucial for function of the maltose ATP-binding cassette transporter (MalFGK2).
  J Biol Chem, 282, 22387-22396.  
17961142 M.L.Daus, S.Berendt, S.Wuttge, and E.Schneider (2007).
Maltose binding protein (MalE) interacts with periplasmic loops P2 and P1 respectively of the MalFG subunits of the maltose ATP binding cassette transporter (MalFGK(2)) from Escherichia coli/Salmonella during the transport cycle.
  Mol Microbiol, 66, 1107-1122.  
18033289 M.L.Oldham, D.Khare, F.A.Quiocho, A.L.Davidson, and J.Chen (2007).
Crystal structure of a catalytic intermediate of the maltose transporter.
  Nature, 450, 515-521.
PDB code: 2r6g
17804665 M.Miethke, and M.A.Marahiel (2007).
Siderophore-based iron acquisition and pathogen control.
  Microbiol Mol Biol Rev, 71, 413-451.  
17255477 M.Rapp, S.Seppälä, E.Granseth, and G.von Heijne (2007).
Emulating membrane protein evolution by rational design.
  Science, 315, 1282-1284.  
18007034 M.Tanabe, O.Mirza, T.Bertrand, H.S.Atkins, R.W.Titball, S.Iwata, K.A.Brown, and B.Byrne (2007).
Structures of OppA and PstS from Yersinia pestis indicate variability of interactions with transmembrane domains.
  Acta Crystallogr D Biol Crystallogr, 63, 1185-1193.
PDB codes: 2z22 2z23
17517781 M.Wiederstein, and M.J.Sippl (2007).
ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins.
  Nucleic Acids Res, 35, W407-W410.  
17159924 O.Lomovskaya, H.I.Zgurskaya, M.Totrov, and W.J.Watkins (2007).
Waltzing transporters and 'the dance macabre' between humans and bacteria.
  Nat Rev Drug Discov, 6, 56-65.  
17485460 P.M.Jones, and A.M.George (2007).
Nucleotide-dependent allostery within the ABC transporter ATP-binding cassette: a computational study of the MJ0796 dimer.
  J Biol Chem, 282, 22793-22803.  
17927448 P.P.Borbat, K.Surendhran, M.Bortolus, P.Zou, J.H.Freed, and H.S.Mchaourab (2007).
Conformational motion of the ABC transporter MsbA induced by ATP hydrolysis.
  PLoS Biol, 5, e271.  
17578454 R.J.Dawson, K.Hollenstein, and K.P.Locher (2007).
Uptake or extrusion: crystal structures of full ABC transporters suggest a common mechanism.
  Mol Microbiol, 65, 250-257.  
17823795 R.Menges, G.Muth, W.Wohlleben, and E.Stegmann (2007).
The ABC transporter Tba of Amycolatopsis balhimycina is required for efficient export of the glycopeptide antibiotic balhimycin.
  Appl Microbiol Biotechnol, 77, 125-134.  
17673622 R.N.Hvorup, B.A.Goetz, M.Niederer, K.Hollenstein, E.Perozo, and K.P.Locher (2007).
Asymmetry in the structure of the ABC transporter-binding protein complex BtuCD-BtuF.
  Science, 317, 1387-1390.
PDB code: 2qi9
18073115 S.Törnroth-Horsefield, P.Gourdon, R.Horsefield, L.Brive, N.Yamamoto, H.Mori, A.Snijder, and R.Neutze (2007).
Crystal structure of AcrB in complex with a single transmembrane subunit reveals another twist.
  Structure, 15, 1663-1673.
PDB code: 2rdd
17523162 S.Y.Morita, A.Kobayashi, Y.Takanezawa, N.Kioka, T.Handa, H.Arai, M.Matsuo, and K.Ueda (2007).
Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4.
  Hepatology, 46, 188-199.  
18058211 Z.E.Sauna, I.W.Kim, and S.V.Ambudkar (2007).
Genomics and the mechanism of P-glycoprotein (ABCB1).
  J Bioenerg Biomembr, 39, 481-487.  
17215884 F.J.Sharom (2006).
Shedding light on drug transport: structure and function of the P-glycoprotein multidrug transporter (ABCB1).
  Biochem Cell Biol, 84, 979-992.  
17139331 G.von Heijne (2006).
Membrane-protein topology.
  Nat Rev Mol Cell Biol, 7, 909-918.  
16971936 S.Schuldiner (2006).
Structural biology: the ins and outs of drug transport.
  Nature, 443, 156-157.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

spacer
spacer