PDBsum entry 2he0

Signaling protein

PDB id: 2he0

Contents

Protein chain

195 a.a. *

Ligands

EDO

Waters ×416

* Residue conservation analysis

PDB id:

2he0

Name:

Signaling protein

Title:

Crystal structure of a human notch1 ankyrin domain mutant

Structure:

Notch1 preproprotein variant. Chain: a, b. Fragment: ankyrin domain, residues 1873-2115. Synonym: human notch ankyrin domain mutant. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: notch 1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.90Å R-factor: 0.190 R-free: 0.231

Authors:

D.Gupta,M.T.Ehebauer,D.Y.Chirgadze,A.Martinez Arias,T.L.Blundell

Key ref:

D.Gupta et al. Crystal structure of a human notch1 ankyrin domain mutant. To be published, .

Date:

21-Jun-06 Release date: 04-Jul-06

Protein chains

P46531  (NOTC1_HUMAN) -  Neurogenic locus notch homolog protein 1 from Homo sapiens

Seq: 2555 a.a.

Struc: 195 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)