PDBsum entry 2fyp

Chaperone

PDB id: 2fyp

Contents

Protein chains

232 a.a. *

Ligands

RDE ×2

PG4 ×8

1PE

Waters ×365

* Residue conservation analysis

PDB id:

2fyp

Name:

Chaperone

Title:

Grp94 in complex with the novel hsp90 inhibitor radester amine

Structure:

Endoplasmin. Chain: a, b. Fragment: n-terminal domain, residues (69-337). Synonym: 94 kda glucose-regulated protein, grp94. Engineered: yes. Mutation: yes

Source:

Canis lupus. Dog. Organism_taxid: 9615. Strain: familiaris. Gene: tra1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.95Å R-factor: 0.230 R-free: 0.265

Authors:

R.M.Immormino,D.T.Gewirth

Key ref:

R.M.Immormino et al. Inhibittory ligands adopt different conformations when bound to hsp90 or grp94: implications for paralog-Specific drug design. To be published, .

Date:

08-Feb-06 Release date: 06-Feb-07

Protein chains

P41148  (ENPL_CANLF) -  Endoplasmin from Canis lupus familiaris

Seq: 804 a.a.

Struc: 232 a.a.*

* PDB and UniProt seqs differ at 12 residue positions (black crosses)