PDBsum entry 2fsd

Viral protein

PDB id

2fsd

Loading ...

Contents

			Protein chains

					110 a.a.

			Waters ×98

PDB id:

2fsd

Links

Name:

Viral protein

Title:

A common fold for the receptor binding domains of lactococcal phages? the crystal structure of the head domain of phage bil170

Structure:

Putative baseplate protein. Chain: a, b. Fragment: rbp head domain, residues 1-113. Synonym: rbp. Engineered: yes

Source:

Unidentified phage. Organism_taxid: 38018. Strain: bil170. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.30Å

R-factor:

0.243

R-free:

0.268

Authors:

S.Ricagno,C.Cambillau

Key ref:

S.Ricagno et al. (2006). Crystal structure of the receptor-binding protein head domain from Lactococcus lactis phage bIL170. J Virol, 80, 9331-9335. PubMed id: 16940545

Date:

22-Jan-06

Release date:

05-Sep-06

PROCHECK

	Headers

	References

Protein chains

O80120 (O80120_9CAUD) - Putative baseplate protein from Skunavirus bIL170

Seq: Struc:					267 a.a. 110 a.a.

Key:

PfamA domain

Secondary structure

CATH domain

	J Virol 80:9331-9335 (2006)
PubMed id: 16940545

Crystal structure of the receptor-binding protein head domain from Lactococcus lactis phage bIL170.
S.Ricagno, V.Campanacci, S.Blangy, S.Spinelli, D.Tremblay, S.Moineau, M.Tegoni, C.Cambillau.

ABSTRACT

Lactococcus lactis, a gram-positive bacterium widely used by the dairy industry, is subject to lytic phage infections. In the first step of infection, phages recognize the host saccharidic receptor using their receptor binding protein (RBP). Here, we report the 2.30-A-resolution crystal structure of the RBP head domain from phage bIL170. The structure of the head monomer is remarkably close to those of other lactococcal phages, p2 and TP901-1, despite any sequence identity with them. The knowledge of the three-dimensional structures of three RBPs gives a better insight into the module exchanges which have occurred among phages.

Literature references that cite this PDB file's key reference

PubMed id

Reference

20351260

G.Sciara, C.Bebeacua, P.Bron, D.Tremblay, M.Ortiz-Lombardia, J.Lichière, M.van Heel, V.Campanacci, S.Moineau, and C.Cambillau (2010).
Structure of lactococcal phage p2 baseplate and its mechanism of activation.

Proc Natl Acad Sci U S A, 107, 6852-6857.

PDB codes:

2wzp 2x53 2x54 2x5a

19740746

D.Veesler, B.Dreier, S.Blangy, J.Lichière, D.Tremblay, S.Moineau, S.Spinelli, M.Tegoni, A.Plückthun, V.Campanacci, and C.Cambillau (2009).
Crystal structure and function of a DARPin neutralizing inhibitor of lactococcal phage TP901-1: comparison of DARPin and camelid VHH binding mode.

J Biol Chem, 284, 30718-30726.

PDB code:

3hg0

19719513

E.Scaltriti, M.Tegoni, C.Rivetti, H.Launay, J.Y.Masson, A.H.Magadan, D.Tremblay, S.Moineau, R.Ramoni, J.Lichière, V.Campanacci, C.Cambillau, and M.Ortiz-Lombardía (2009).
Structure and function of phage p2 ORF34(p2), a new type of single-stranded DNA binding protein.

Mol Microbiol, 73, 1156-1170.

PDB codes:

2wkc 2wkd

19542338

G.M.Rousseau, and S.Moineau (2009).
Evolution of Lactococcus lactis phages within a cheese factory.

Appl Environ Microbiol, 75, 5336-5344.

19047351

M.Siponen, G.Sciara, M.Villion, S.Spinelli, J.Lichière, C.Cambillau, S.Moineau, and V.Campanacci (2009).
Crystal structure of ORF12 from Lactococcus lactis phage p2 identifies a tape measure protein chaperone.

J Bacteriol, 191, 728-734.

PDB code:

3d8l

19286807

M.Siponen, S.Spinelli, S.Blangy, S.Moineau, C.Cambillau, and V.Campanacci (2009).
Crystal structure of a chimeric receptor binding protein constructed from two lactococcal phages.

J Bacteriol, 191, 3220-3225.

PDB codes:

3d8m 3da0

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.